A Clinical Atlas of 101 Common Skin Diseases
Chapter 1. Acanthosis Nigricans
Integration: Unifying Concept
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Acanthosis nigricans tends to persist unless its cause is identified and corrected. For example, lesions of acanthosis nigricans secondary to an endocrine disorder, such as diabetes mellitus or hypothyroidism, disappear when that abnormality has been remedied by appropriate hormonal therapy. Lesions consequent to the effects of a malignant neoplasm in an internal organ, such as an adenocarcinoma of the stomach or the colon, may regress entirely after complete surgical extirpation of the inciting neoplasm, if that neoplasm has not yet metastasized.
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