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Scleroderma (morphea) Scleredema (Buschke) 1. Dermis thickened slightly 1. Dermis thickened markedly, sometimes three or more times normal 2. Collagen bundles thickened markedly 2. Collagen bundles thickened only slightly 3. Collagen bundles packed; spaces between them narrow 3. Collagen bundles not crowded; spaces between them even widened 4. Epithelial structures of adnexa often absent 4. […]