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Images 10.46.1A: Perivascular dermatitis, interface, vacuolar + 10.46.1B: Edema of the papillary dermis, lymphocytes along the dermoepidermal junction, ballooning of keratocytes, and many individual necrotic keratocytes = Hand-foot-and-mouth disease The changes of an early lesion of hand-foot-and-mouth disease, such as this one, resemble closely those of erythema multiforme. In hand-foot-and-mouth disease, however, necrotic keratocytes are […]