Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

Overview Hailey-Hailey disease (HHD), also called benign familial pemphigus, is an autosomal-dominant disorder characterized by a defect in keratinocyte adhesion. HHD most frequently involves intertriginous areas, where exacerbations are triggered b…

A Clinical Atlas of 101 Common Skin Diseases

Phototoxic Dermatitis

An inflammatory process that represents the combined effects of a toxic substance applied topically or administered systemically in combination with the effects of ultraviolet light, the result being a caricature of sunburn. The lesions consist of e…

Histologic Diagnosis of Inflammatory Skin Diseases

Burns

Burns Synonyms Thermal injuries Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Regions that usually are exposed rather than covered Configuration of lesions Depends on the particular type of burn; bizarre shape…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…llooned keratocytes and confluent epidermal necrosis = Thermal burn This is not a true dermatitis because there is no infiltrate of inflammatory cells. It is a first-degree burn because the changes are confined to the epidermis. That the lesion devel…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

“An irreversible alopecia of the scalp occurs in negro women who straighten their hair with hot combs. The disease is common and distinctive, clinically and histopathologically. . . . Hot petrolatum used with the comb causes a chronic inflamm…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…z #229) Bullous pemphigoid, vesiculo-bullous stage (Quiz #230) Burn, first-degree, repeated countless times for many years (erythema ab igne) (Quiz #347) Burn, second-degree, consequent to contact repeatedly with a hot grill for many months (erythema…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Dermatology Practical & Conceptual

A reticulated pigmented rash on the lower leg

Quiz case A 10-year-old boy presented to the dermatologist for a spider web-like pigmented rash on the lower right leg. On examination it was found that the rash was expanding medially from the lateral aspect of the leg to ventral part of the foot (…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…