Therapeutic Strategies in Dermatology

Psoriasis: Clinical Overview

Clinical Overview Psoriasis is a chronic, intermittent skin disease classically marked by sharply-demarcated erythematous papules and plaques with silvery hyperkeratotic scale that affects the scalp, ears, palms, soles, elbows, knees, and interglut…

Therapeutic Strategies in Dermatology

Psoriasis: Key Points

Key Points Psoriasis is a chronic inflammatory disease which can affect the skin, joints and nails Psoriasis typically affects the scalp, ears, palms, soles, elbows, knees, and intergluteal cleft; it can result in erythroderma (generalized erythema…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

Overview Hailey-Hailey disease (HHD), also called benign familial pemphigus, is an autosomal-dominant disorder characterized by a defect in keratinocyte adhesion. HHD most frequently involves intertriginous areas, where exacerbations are triggered b…

Therapeutic Strategies in Dermatology

Darier’s Disease: Key Points

Darier’s disease is a genodermatosis of autosomal dominant inheritance causing abnormalities of keratinization stemming from defects in calcium regulation in keratinocytes. The classic skin manifestation is an eruption of hyperkeratotic papules, ty…

A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…ic acanthoma, a solitary keratosis. Figure 5.274 A&B. A cleft in Grover’s disease: an empty space. In contrast to a blister that contains material of some kind, e.g., serum, fibrin, and inflammatory cells, a cleft contains nary a thing….

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…being benign, as is the case for large nodular trichoblastoma. Clefts are thought to result from retraction of elements of tissue during fixation or during processing of a specimen. Figure 3.9 Cleft (suprabasal). COARSE COLLAGEN BUNDLES IN VERTICA…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.44.1A: Perivascular dermatitis, sparse + 10.44.1B: A suprabasal cleft, acanthotic dyskeratotic cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis iden…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…eventuates in a subepidermal blister may be associated with a cleft. Parenthetically, any process that results in poor adhesion of epithelial cells and dermis, e.g., basal-cell carcinoma, may be associated with clefts. Click image to enlarge. + Fibr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.60.10B: Lymphocytes along the dermoepidermal junction, cleft, wedge-shaped hypergranulosis, and compact orthokeratosis = Lichen planus, fully developed  The cleft resulted from extensive vacuolar alteration. It is not a subepidermal blister b…