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Therapeutic Strategies in Dermatology

Psoriasis: Clinical Overview

…he scalp, ears, palms, soles, elbows, knees, and intergluteal cleft; it usually spares the face in adults, but may involve the face in approximately half of affected children. Arthritis is associated with psoriasis in 10-30% of patients, and nail inv…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Overview

…y is particularly useful for lesions in the axillae, buttocks cleft, and groin. Surgical excision and possibly photodynamic therapy can produce similar results. For very severe cases, systemic corticosteroids (1 mg/kg/day prednisone) can lead to impr…

Therapeutic Strategies in Dermatology

Psoriasis: Key Points

…he scalp, ears, palms, soles, elbows, knees, and intergluteal cleft; it can result in erythroderma (generalized erythema) or be pustular. Initial treatment of psoriasis is followed by long-term maintenance therapy. Greater than 10% body surface area,…

Therapeutic Strategies in Dermatology

Darier’s Disease: Key Points

…ds, retroauricular neck, upper trunk, groin, and intergluteal cleft. Involvement of intertriginous sites can result in vegetative plaques. Other clinical variants include a cornifying variant, characterized by hypertrophic, vegetative lesions, primar…

A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…nified layers of diseases typified by formation of suprabasal clefts, rather than by actual blisters, examples of that phenomenon being “acantholytic dyskeratosis” encountered in such different disorders as Darier’s disease (Fig. 5….

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…eventually dying, the process ending in formation of either a cleft or a blister (Fig. 3.3). Figure 3.3 Acantholysis. Cells in the spinous, granular, and cornified layers of the epidermis and of epithelial structures of adnexa are the ones that us…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…egenerated collagen, deposits of lipid, including cholesterol clefts, and necrosis of inflammatory cells, lymphocytes and plasma cells especially, all of which make up a nodular and diffuse infiltrate = Necrobiotic xanthogranuloma + Histiocytes wit…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…Perivascular dermatitis, sparse + 10.44.1B: A suprabasal cleft, acanthotic dyskeratotic cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis identical with those picture…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…B: Obscuration of the dermoepidermal junction by lymphocytes, clefts, jagged acanthosis, hypergranulosis, and orthokeratosis = Lichen planus, early┬áIn an early lesion of lichen planus, the lichenoid infiltrate of lymphocytes is focal; in a fully-deve…

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