Search Results for: collagen

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Therapeutic Strategies in Dermatology

Necrobiosis Lipoidica Diabeticorum: Key Points

…ered collagen and inflammation. The dermis is filled with alternating bands of inflammatory cells and altered, “necrobiotic” collagen, which appears as homogenized pink bands. The inflammatory component may have palisades of histiocytes and giant…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

…r matrix and is confined to a narrow zone in the papillary dermis near the basement membrane, in close proximity to Type VII collagen and to collagen of blood vessels. Type XVII collagen is a transmembrane protein characterized by alternating…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…or subepidermal, house serum, which, when it ascends to the surface of the skin, takes the form of a crust. WIRY BUNDLES OF COLLAGEN IN HAPHAZARD ARRAY: Collagen bundles that resemble wires arranged randomly in the upper part of the dermis, often…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….20.27B: Sclerosis in the center of the dermal component and a proliferation of fibrocytes in company with coarse bundles of collagen at the periphery of it + 10.20.27C + 10.20.27D = Dermatofibroma The ribbon-like bundles of collagen in fascicles…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…center of tiny palisaded granulomas = Interstitial granulomatous dermatitis with arthritis + Histiocytes around degenerated collagen (early) and around thickened bundles of collagen (late), and a perivascular lymphoplasmacytic infiltrate =…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…an inflammatory process because it is devoid of inflammatory cells. Error: Connective tissue disease is a worthy synonym for collagen-vascular disease. Reason: Certain hamartomas of collagen (e.g., that connective tissue nevus known badly as…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…unlight. 10.43.16A: Perivascular and interstitial dermatitis + 10.43.16B: Lymphocytes around venules and histiocytes between collagen bundles = Granuloma annulare Abundant mucin is present between collagen bundles in foci of infiltration by…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…formulated, and never will be. Among the many reasons for that is an impenetrable language that includes “necrosis of collagen,” “necrobiotic collagen bundles,” and “basophilic necrotizing fibrinoid material.” It…

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