Search Results for: dyskeratosis

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Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Clinical Case

…ure from crusted area Follow-up evaluation H&E demonstrates intraepidermal and suprabasal acantholysis without prominent dyskeratosis Bacterial culture was negative Initiate treatment with: aluminum chloride 20% solution, clindamycin 1%,…

Therapeutic Strategies in Dermatology

Grover’s Disease / Transient Acantholytic Dermatosis: References

…te G, Cornelius L (2012). Unusual complication of vemurafenib treatment of metastatic melanoma: exacerbation of acantholytic dyskeratosis complicated by Kaposi varicelliform eruption, JAAD, 148:966-968. Norman R and Chau V (2011). Use of etanercept…

Therapeutic Strategies in Dermatology

Darier’s Disease: Key Points

…ticulum; the resulting disruption in calcium homeostasis in keratinocytes results in poor cell-cell adhesion with subsequent dyskeratosis affecting skin, nails, and mucous membranes. The hallmark skin lesion is a hyperkeratotic papule. The diagnosis…

Therapeutic Strategies in Dermatology

Darier’s Disease: References

…IJD, 44:184-192. Savignac M, Edir A, Simon M, Hovnanian A. (2011). Darier disease: a disease model of impaired calcium homeostasis in the skin, Biochimica et Biophysica Acta, 1813:1111-1117. Zeglaoui F, Zaraa I, Fazaa B, et al. (2005). Dyskeratosis

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Key Points

…s extending down to the suprabasal level, producing the characteristic “dilapidated brick wall” appearance in the epidermis. Dyskeratosis is not a prominent feature, in contrast to the findings seen in Darier’s disease. As HHD is not an…

Dermoscopic clues to diagnose acantholytic dyskeratosis

Dermoscopic clues to diagnose acantholytic dyskeratosis

…One theory is that the accumulation in the skin of chemotherapy metabolites by sweating may be related to the development of dyskeratosis and acantholysis; another theory supposes that acantholytic dyskeratosis may represent an off-target effect of…

A Clinical Atlas of 101 Common Skin Diseases

Darier’s Disease

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

A Clinical Atlas of 101 Common Skin Diseases

Porokeratosis

A constellation of conditions that assumes various forms clinically but whose most dependable denominator in common (the exception being the punctate manifestation) is a keratotic ring around a central zone of atrophy, e.g., in a congenital…

A Clinical Atlas of 101 Common Skin Diseases

Palmar and Plantar Keratoderma

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate.

A Clinical Atlas of 101 Common Skin Diseases

Epidermal Nevi

Epidermal nevi are hamartomas in which the epidermis is abnormal, being hyperkeratotic, and in which lesions are aligned along Blaschko’s lines.

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