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Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…ial infiltrate of lymphocytes, plasma cells, neutrophils, and eosinophils = Tick bite reaction + Keratocytes with steel-gray nuclei and “margination” of chromatin or even with no epidermal changes, but edema of the papillary dermis and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ar and interstitial dermatitis + 10.5.1B: Lymphocytes and eosinophils around venules, and neutrophils in the interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod assaultĀ  Lysosomal enzymes releas…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…ar and interstitial infiltrate in which lymphocytes and a few eosinophils are present around venules and eosinophils are scattered in the interstitium should call to mind pruritic urticarial papules and plaques of pregnancy (PUPPP) (Fig. 5.27 A&B…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…response to a “bite” of an insect Lymphocytes and eosinophils around venules, and eosinophils scattered in the interstitium of the reticular dermis; a few neutrophils may be discernible Slight edema of the papillary dermis A discrete focu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…. Histologically there is oedema and dermal infiltration with eosinophils. The resolving stage of granulomatous dermatitis lasts about six weeks with brawny, slate coloured oedema. Histologically the dermis is infiltrated with eosinophils and histioc…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…Perivascular and interstitial infiltrate of lymphocytes and eosinophils Eosinophils scattered throughout the upper part of the reticular dermis, in the edematous papillary dermis, and along the dermoepidermal junction Eosinophils often in the epide…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…nflammatory cells (in this instance mixed, of lymphocytes and eosinophils) is irrelevant to coming to that diagnosis with specificity. As a rule, however, eosinophils complement lymphocytes. In most instances, the place where a blister resides within…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…terface, vacuolar, and spongiotic + 10.10.1B: Innumerable eosinophils in the edematous papillary dermis and in the acanthotic epidermis = Bullous pemphigoid, urticarial Eosinophils in the epidermis induce spongiosis that, at times, leads to forma…

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