1 2 3 10
Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…A&B). Fibrosing dermatitis may result from the effects on fibrocytes of infiltrates of inflammatory cells of long standing, as occurs in diseases as different as lichen planus (especially the infundibulo- and folliculocentric expression of that d…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….20.1B: Numerous extravasated erythrocytes, siderophages, and fibrocytes = Dermatofibroma An important finding for diagnosis of a dermatofibroma such as this one is seen at the periphery of the lesion, namely, thickened bundles of collagen that seem…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ells, basophils, Langerhans” cells, dermal dendrocytes, fibrocytes, and platelets should be considered inflammatory cells is a matter yet unresolved. We address here those cells that may participate in inflammatory diseases and, in particular,…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…gen, as it is purported to be, but rather a faulty product of fibrocytes. Degeneration of cells designates injury that may not necessarily be fatal, i.e., the cells are not yet dead and, therefore, are able to recover fully, as in examples of balloon…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s 10.96.1A: Fibrosing dermatitis + 10.96.1B: Plump fibrocytes, coarse bundles of collagen in haphazard array, and patchy infiltrate of iron-containing macrophages = Scar, very early ¬†Innumerable macrophages replete with iron bear testimony…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

…ed lobules in the subcutaneous fat Interstitial infiltrate of fibrocytes throughout the dermis and in septa of the subcutaneous fat; sometimes also in fascia and skeletal muscle Fibrocytes with plump oval monomorphous nuclei increased markedly in num…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…d panniculitis, septal + 10.92.1B: Numerous multinucleate fibrocytes with large, hyperchromatic, pleomorphic nuclei = Radiation dermatitis, chronic ¬†Abnormal fibrocytes, some of them multinucleate, are effects of longstanding injury by radiation….

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…ire dermis and part of the subcutaneous fat Bizarre-appearing fibrocytes with abnormal nuclei and stellate cytoplasm in zones of sclerosis Decreased number of epithelial structures of adnexa Subepidermal fibrin often Vacuolar alteration along the der…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…tes, some of which may be siderophages and/or lipophages, and fibrocytes in a nodule in the reticular dermis and, at times, the upper part of the subcutaneous fat Some histiocytes may be multinucleate, e.g., Touton giant cells that often contain hemo…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…skin, i.e., Langerhans” cells, macrophages, mast cells, fibrocytes, blood vessels, lymph vessels, muscles, and adipocytes originate from mesoderm. In a 3-week-old embryo, the primordial epidermis consists of a single layer of flattened epitheli…

1 2 3 10