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Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…g dermopathy is marked early in its course by proliferation of fibrocytes floridly and in interstitial fashion in the skin and subcutis (Fig. 5.362 A&B). Episodically, skeletal muscle is punctuated by plump oval, monomorphous fibrocytes and in th…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hages and siderophages, some of them multinucleate, as well as fibrocytes = Dermatofibroma Lipophages and siderophages bear testimony to bleeding into the skin as a consequence of injury at the site. At the periphery of the lesion, fibrocytes and his…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…ls such as those that make bone, cartilage, and muscle. Dermal fibrocytes are engaged in synthesis, degradation, and remodeling of connective tissue in skin. Recently, however, it has been proposed the fibrocytes may be derivatives of circulating mon…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…osed randomly and affiliated with an increased number of plump fibrocytes that parallel the long axis of the thickened bundles. A dermatofibroma is another type of fibrosis in which coarse collagen bundles and many fibrocytes are arranged haphazardly…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ue. 10.96.2A: Fibrosing dermatitis + 10.96.2B: Plump fibrocytes, coarse bundles of collagen in haphazard array, and abundant mucin in interstices between collagen bundles = Scar, early ¬†As lesions of scars and keloids evolve, fibrocytes not…

Histologic Diagnosis of Inflammatory Skin Diseases

Nephrogenic fibrosing dermopathy

…ted lobules in the subcutaneous fat Interstitial infiltrate of fibrocytes throughout the dermis and in septa of the subcutaneous fat; sometimes also in fascia and skeletal muscle Fibrocytes with plump oval monomorphous nuclei increased markedly in nu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nd panniculitis, septal + 10.92.1B: Numerous multinucleate fibrocytes with large, hyperchromatic, pleomorphic nuclei = Radiation dermatitis, chronic ¬†Abnormal fibrocytes, some of them multinucleate, are effects of longstanding injury by radiation…

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…iodermatitis is accompanied by an increased number of peculiar fibrocytes marked by abnormal nuclei and abundant, often stellate-shaped cytoplasm. Some fibrocytes are binucleate. Other findings encountered often in longstanding radiodermatitis are fi…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…s, the upper part of the subcutaneous fat Collagen bundles and fibrocytes sometimes arrayed in short fascicles that interweave Fibrocytes interposed between thickened collagen bundles at the periphery of the lesion Sclerosis sometimes in the center o…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…d connective tissue. By 24 weeks, elastic fibers, made also by fibrocytes, first become visible among collagen bundles in the dermis. Dermal dendrocytes, a heterogeneous population, are indistinguishable by conventional microscopy from fibrocytes and…

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