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A Clinical Atlas of 101 Common Skin Diseases

Histiocytosis X

A proliferation of abnormal Langerhanscells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Oral Hairy Leukoplakia: Key Points

…gan transplant recipients. Increased numbers of EBV-infected B cells and reduced numbers of EBV-specific cytotoxic T cells noted in biopsies of OHL, in addition to the absence or reduced number of Langerhans cells, suggest key immunologic factors ass…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

cells, lymphocytes in particular. The term “inflammatory cells” is understood as being generic for neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes; whether mast cells, basophils, Langerhanscells, dermal dendro…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhanscells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

Histologic Diagnosis of Inflammatory Skin Diseases

Merkel Cells

…bsence of any seeming association with neural elements. Merkel cells appear in fetal skin by the 16th week of gestation, and, unlike melanocytes, they do not come from the neural crest, and, unlike Langerhanscells, they do not come from the b…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…, 2nd ed. Sydney: Churchill Livingstone: 2002:1079. The term Langerhans’ cell granulomatosis is in vogue for diseases characterized by infiltrates in which Langerhanscells predominate, namely, Letterer-Siwe disease, Hand-Sch?ller-Chri…

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