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A Clinical Atlas of 101 Common Skin Diseases

Melanocytic Nevi and Melanotic Macules

Hamartomas (“congenital” melanocytic nevi) and benign neoplasms (“acquired” melanocytic nevi) of various specific types, all of which are composed of abnormal melanocytes and manifested clinically as lesions of different colo…

A Clinical Atlas of 101 Common Skin Diseases

Melanoma

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

A Clinical Atlas of 101 Common Skin Diseases

Vitiligo

An inflammatory process that is idiopathic and results in depigmentation of the skin consequent to loss of melanocytes from the epidermis, and in whitening of hair that follows loss of melanocytes from the bulb of follicles….

A Clinical Atlas of 101 Common Skin Diseases

Melasma

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

Therapeutic Strategies in Dermatology

Melanoma: Key Points

Key Points The therapy of malignant melanoma is determined by the histopathologic features (tumor thickness, depth of invasion, ulceration, regression, mitotic index), by the location of the tumor, by the presence of regional or distant metastases,…

Therapeutic Strategies in Dermatology

Facial Melanosis, Melasma: Key Points

Key Points Facial melanosis (also known as melasma) is a very common condition. In the USA, 5 to 6 million individuals are affected. Melasma usually appears in association with oral contraceptive (OCP) use or pregnancy (“chloasma,” or t…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

Overview Mastocytosis results from systemic or localized mast cell proliferation. The natural history and pathogenesis of cases occurring in childhood (before age 2) and cases occurring in adults is distinctly different. Childhood cases are usually…

Histologic Diagnosis of Inflammatory Skin Diseases

Melanocytes

Melanocytes synthesize melanin. From precursors in the neural crest, melanocytes migrate normally to the epidermis, the bulb of hair follicles, epithelia of various mucous membranes, leptomeninges, inner ear, and a few other tissues (Fig. 1.61). Pri…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blue Nevus?

…are cellular in the sense that all of them are constituted of melanocytes. If a melanocytic nevus must consist of nests and fascicles of melanocytes, and at times of columns, cords, and strands of them, then “common” blue nevus, unlike &…

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