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Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

Both somatic sensory and autonomic motor nerves are present in skin (Fig. 1.82). The somatic sensory system mediates sensations of pain, itch, temperature, light touch, discriminative touch, pressure, vibration, and proprioception. Nerves of the aut…

A Clinical Atlas of 101 Common Skin Diseases

Neurofibromatosis

A constellation of lesions that represent disorders of melanocytes (e.g., axillary "freckles" and café au lait "spots") and of proliferations of Schwann cells (e.g., papules, nodules, and tumors of neurofibroma). The cutaneous lesions may be accompanied by neoplasms with neural differentiation that are situated in nerves (e.g., acoustic neuroma) and in the brain (e.g., gliomas), […]

A Clinical Atlas of 101 Common Skin Diseases

Leprosy

An inflammatory disease caused by Mycobacterium leprae. It can involve internal organs or be localized to the skin, where its clinical presentation is dependent on the immunologic status of the host. Persons who are competent immunologically have pa…

Dermatology Practical & Conceptual

Notalgia paresthetica: the unreachable itch

Abstract Background: Notalgia paresthetica (NP) is a very common, under-recognized condition characterized by pruritus in a unilateral, dermatomal distribution in the mid-back. Chronic pruritus is sometimes accompanied by pain, paresthesias, or alte…

Dermatology Practical & Conceptual

Enlarging plaque on the face with enlarged supraorbital nerve

…g to impairments and permanent disability [1]. The most common nerves involved in RR are the median, radial and ulnar nerves, the sural, posterior tibial and perineal nerves, great auricular and the facial nerve. In all leprosy patients, accurate neu…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…s, an elaborate neural network is fashioned of autonomic motor nerves that innervate blood vessels, muscles of hair erection, eccrine and apocrine glands, somatic sensory nerves, and specialized sensory end organs, e.g., Pacini’s corpuscles, Me…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

Leprosy Synonyms Hansen’s disease Lepra Presentation stereotypical Age and sex Young adults of both sexes who live in endemic areas Distribution of lesions Localized in indeterminate and tuberculoid types; widespread and symmetrical in lepro…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atopic Dermatitis?

“In America, some of the designations employed [for atopic dermatitis] are: ‘pruritus with lichenification,’ ‘allergic eczema,’ ‘atopic eczema,’ ‘hay fever eczema,’ ‘flexural eczema,&#821…

Differential Diagnosis in Dermatopathology

Tuberculoid leprosy vs. Sarcoidosis

An inflammatory disease caused by Mycobacterium leprae. It can involve internal organs or be localized to the skin, where its clinical presentation is dependent on the immunologic status of the host. Persons who are competent immunologically have pa…

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