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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mycosis Fungoides—Increasing in Incidence?

“Mycosis fungoides does appear to be increasing in frequency more rapidly than lymphoma in general.” Weinstock MA. Epidemiology of mycosis fungoides. Semin Dermatol 1994;13(3):154–59. “The incidence [of mycosis fungoides…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Discoid lupus erythematosus Dermatomyositis 1. Infundibula dilated commonly by plugs of cornified cells 1. Infundibula not plugged by cornified cells 2. Follicles atrophy and disappear consequent to the effects of products of lymphocytes 2. Fo…

Differential Diagnosis in Dermatopathology

Discussions

Lichen planus and lichenoid discoid lupus erythematosus have many findings histopathologic in common, among them hyperkeratosis of surface epidermis and plugs of cornified cells in infundibular epidermis; individual necrotic keratocytes; a lichenoid…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

Lupus erythematosus Synonyms Lupus erythematodes Presentation stereotypical Age and sex Young adult women especially, but sometimes neonates and older persons of both sexes. Distribution of lesions Often localized to sun-exposed sites such as the fa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

“Perforating dermatoses: . . . various cutaneous disorders are discussed in which the process of perforation and elimination of various tissue components plays a major role in the basic pathologic mechanism. These include perforating granulom…

Differential Diagnosis in Dermatopathology

Discussions

In a collagenous type of connective tissue nevus, known also as collagenoma, and in a lesion late in the course of morphea, abnormalities of connective tissue are observed mostly in the dermis. Bundles of collagen are thickened throughout the reticu…

Differential Diagnosis in Dermatopathology

Discussions

Both sebaceous hyperplasia and nevus sebaceus of Jadassohn consist of abnormalities of sebaceous glands but the former, as the name denotes, is a hyperplasia, whereas the latter is a hamartoma that involves not only sebaceous units, but other adnexa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

“The occurrence of a clinical syndrome of severe asthma, fever, and hypereosinophilia, together with symptoms of vascular embarrassment in various organ systems, has been established. . . . The basic anatomical changes . . . consisted of wide…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Sebaceous hyperplasia Nevus sebaceus of Jadassohn 1. Dome-shaped papule with a central cell 1. Relatively flat-topped plaque in early stage; papillated or digitated plaque in fully developed and later stages; no dell 2. Basket-woven pattern of…

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