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Histologic Diagnosis of Inflammatory Skin Diseases

Borreliosis (erythema migrans)

Borreliosis (erythema migrans) Presentation stereotypical Age and sex Any age and either sex Distribution of lesions Nearly anywhere, but mostly the lower extremities; involvement of face and scalp is more common in children Configuration of lesions…

Differential Diagnosis in Dermatopathology

Lichen sclerosus et atrophicus vs. Superficial morphea

A granulomatous inflammatory process characterized clinically by patches that become yellowish plaques and that in time resolve with atrophy and telangiectases. The condition usually occurs in persons with diabetes….

Dermatology Practical & Conceptual

A verrucous plaque on the lower leg

Quiz case A 52-year-old male patient from South Africa presented with a lesion on his lower left leg extending from the ankle to just below the knee that has been present for twenty years. The lesion first developed as a verrucous nodule close to th…

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

Degos’ disease (malignant atrophic papulosis) Synonyms Degos’ syndrome Malignant atrophic papulosis Papulosis atrophicans maligna Koehlmeier-Degos syndrome Thromboangiitis cutaneointestinalis disseminata Fatal cutaneointestinal syndrome…

Differential Diagnosis in Dermatopathology

Necrobiosis lipoidica vs. Necrobiotic xanthogranuloma

A granulomatous inflammatory process characterized clinically by patches that become yellowish plaques and that in time resolve with atrophy and telangiectases. The condition usually occurs in persons with diabetes….

Differential Diagnosis in Dermatopathology

Discussions

The panniculitis of lupus erythematosus, known conventionally as lupus profundus, and the panniculitis of morphea, referred sometimes to as morphea profundus, have several findings histopathologic in common: infiltrates of lymphocytes and plasma cel…

Histologic Diagnosis of Inflammatory Skin Diseases

Post-inflammatory pigmentary alteration

Post-inflammatory pigmentary alteration Synonyms Postinflammatory pigmentary change Presentation stereotypical Age and sex No preference for age or sex, more prominent in dark-skinned individuals Distribution of lesions Sites of a previous dermatiti…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus foliaceus

Pemphigus foliaceus Presentation stereotypical Age and sex Adults usually and of both sexes Distribution of lesions Localized to photodistribution in pemphigus erythematosus; widespread in pemphigus foliaceus Individual lesions Macules, patches, fla…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Discoid lupus erythematosus Dermatomyositis 1. Infundibula dilated commonly by plugs of cornified cells 1. Infundibula not plugged by cornified cells 2. Follicles atrophy and disappear consequent to the effects of products of lymphocytes 2. Fo…

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