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Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es and patches. They may be followed by blisters secondary to ballooning and spongiosis, and then by ulcers. When the process resolves with fibrosis, as it does in the course of many months or years, the condition is termed “atrophie blanche&#8…

Differential Diagnosis in Dermatopathology

Discussions

…perivascular infiltration by inflammatory cells, spongiosis, ballooning, and necrosis of individual keratocytes of the epidermis (surface and infundibular) and in the upper part of eccrine ducts. Eosinophils may be present in both diseases, commonly…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

…rt of the dermis Edema of the papillary dermis Spongiosis and ballooning sometimes resulting in intraepidermal vesiculation Epidermis necrotic often Late Sparse infiltrate of lymphocytes mostly in the upper part of the dermis Sclerosis in the upper…

Differential Diagnosis in Dermatopathology

Discussions

…ults, never as vesicles. Spongiosis (intercellular edema) and ballooning (intracellular edema) are met with commonly in Mucha-Habermann disease, but not in secondary syphilis. Scattered, individual necrotic keratocytes and even confluent necrosis of…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Lymphomatoid papulosis

Papules, nodules, vesicles, and sometimes bullae that develop in response to “bites” of arthropods, among the most common offenders being mosquitoes, bedbugs, and mites of scabies….

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis enteropathica

…relation clinicopathologic Blisters occur secondary to marked ballooning of keratocytes in the upper half of the viable epidermis. Pustules form consequent to neutrophils having been attracted chemotactically to necrotic ballooned keratocytes. Scale-…

Differential Diagnosis in Dermatopathology

Discussions

…parakeratosis, necrosis of epidermal keratocytes, spongiosis, ballooning, and edema of the papillary dermis. The major difference between the two very unalike processes pathologic is that lymphomatoid papulosis, a CD30 lymphoma, is associated with in…

Differential Diagnosis in Dermatopathology

Discussions

…tic keratocytes and even confluent necrosis of the epidermis, ballooning, intraepidermal vesiculation, and neutrophils in zones of parakeratosis. Each of those findings signals a process that is active and dynamic. Clinically, lesions of pityriasis l…

Histologic Diagnosis of Inflammatory Skin Diseases

Staphylococcal scalded skin syndrome

…thema multiforme may develop in the spinous zone secondary to ballooning and spongiosis or at the dermoepidermal junction consequent to the effects of extensive vacuolar alteration; at times, the blister appears at both sites concurrently. Both condi…

Differential Diagnosis in Dermatopathology

Discussions

…o-called intra- and intercellular edema, i.e., spongiosis and ballooning, edema of the papillary dermis, and superficial perivascular mixed-cell infiltrates. Both also may be associated with subepidermal vesiculation consequent to rupture of intraepi…

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