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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nuclear Atypia, Cytoplasmic Atypia, and Architectural Atypia?

…The nuclear change may be the only discernible alteration, for such cells may be either larger or smaller than normal and otherwise unaltered.” Ewing J. General pathology of epithelial tumors. In: Neoplastic Diseases. Philadelphia, PA: WB Saun…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…icult to accept. If, on the other hand, the LC is considered a specific histiocytic cell which normally occurs within the connective tissues and within stratified squamous epithelia it could be assumed that HX is a disease in which these particular c…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…remalignant dysplasia).” Elder DE, Murphy GF. Malignant tumors (melanomas and related lesions). In: Atlas of Tumor Pathology: Melanocytic Tumors of the Skin. Washington, D.C.: Armed Forces Institute of Pathology, 1991; Third Series, Fascicle 2…

Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

…melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nod…

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