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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…scattered along the dermoepidermal junction beneath a thinned epidermis that displays slight compact orthokeratosis, and mucin in abundance in the reticular dermis. Still later, the basement membrane beneath the epidermis and around infundibula and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…of those blisters tends to become gray as a consequence of the epidermis having undergone necrosis. In his atlas of dermatopathology published in the 1950s, Achilles Civatte pictured erythema multiforme histopathologically as a lesion with an epiderm…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

…infundibula by orthokeratotic cells Acanthosis of infundibular epidermis Spongiosis of infundibular epidermis, including spongiotic vesiculate. Cornoid lamellation in infundibula sometimes Ballooning and vacuolar alteration, and individual dyskeratot…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.47.1A: Perivascular dermatitis, interface, patchy lichenoid + 10.47.1B: Keratocytes with steel-gray nuclei, “margination” of chromatin, ballooned cytoplasm, and multinucleate and necrotic keratocytes = Infection by h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo?

“Because lentigines are larger and more variegated than true freckles, they are not uncommonly biopsied to exclude melanocytic dysplasia or radial growth phase melanoma, such as lentigo maligna.” Murphy G. Melanocytic tumors. In: Derma…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…kocytoclastic vasculitis, fully developed Beneath the necrotic epidermis, marked by a red rather than a blue hue as is seen normally, there are signs of re-epithelialization of the epidermis. The innumerable erythrocytes extravasated are responsible…

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