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Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

Leprosy Synonyms Hansen’s disease Lepra Presentation stereotypical Age and sex Young adults of both sexes who live in endemic areas Distribution of lesions Localized in indeterminate and tuberculoid types; widespread and symmetrical in lepro…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

“Eleven out of 17 presented with chilblain LE after the development of facial discoid LE and the delay varied from 1 to 14 years (mean 5.9 years). . . . Three patients had chilblains and bad circulation before the onset of LE. The sites of th…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ial cells sometimes protrude into the lumen of vessels 9. No fibrin around venules in the upper part of the dermis 9. Fibrin sometimes present around venules in the upper part of the dermis 10. Number of blood vessels in the reticular dermis seem…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…te histiocytes as a rule 7. Mucin, degenerated collagen, and fibrin in the center of palisades 7. No mucin, degenerated collagen, or fibrin in the center of palisades 8. Remnants of collagen preserved in zones replete with granular, stringy mater…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.78.1A: Perivascular and interstitial dermatitis, lymphocytic + 10.78.1B: Numerous extravasated erythrocytes in conjunction with a monomorphous population of lymphocytes = Schamberg’s disease, early  This is but one of seve…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…For one, Mucha-Habermann disease is not a vasculitis, because fibrin is not present in the wall of venules and thrombi are not found within the lumen of them. The presence rarely of fibrin in the wall of one or two vessels in the context of a periva…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…21; of neutrophils in perivascular and interstitial locale. If fibrin is present in the wall of venules, the diagnosis is leukocytoclastic vasculitis, not lupus erythematosus or Sweet’s syndrome. If no fibrin is present, which is the rule in ve…

Histologic Diagnosis of Inflammatory Skin Diseases

Pernio

Pernio Synonyms Dermatitis congelationis Chilblains Chilblain lupus Perniosis Erythema pernio Presentation stereotypical Age and sex Young persons usually with no predilection for either sex Distribution of lesions Fingers, toes, nose, and ears In…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent pigmented purpuric dermatitis

Persistent pigmented purpuric dermatitis Synonyms Pigmented purpuric dermatitis Progressive pigmentary dermatosis Progressive pigmented prupura Dermatosis pigmentaria progressiva Presentation stereotypical Age and sex Adults of both sexes; childre…

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