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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

“Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. . . . The overall picture was nonspecific and ranged from one suggestive of eryt…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ial cells sometimes protrude into the lumen of vessels 9. No fibrin around venules in the upper part of the dermis 9. Fibrin sometimes present around venules in the upper part of the dermis 10. Number of blood vessels in the reticular dermis seem…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…te histiocytes as a rule 7. Mucin, degenerated collagen, and fibrin in the center of palisades 7. No mucin, degenerated collagen, or fibrin in the center of palisades 8. Remnants of collagen preserved in zones replete with granular, stringy mater…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.78.1A: Perivascular and interstitial dermatitis, lymphocytic + 10.78.1B: Numerous extravasated erythrocytes in conjunction with a monomorphous population of lymphocytes = Schamberg’s disease, early  This is but one of seve…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…For one, Mucha-Habermann disease is not a vasculitis, because fibrin is not present in the wall of venules and thrombi are not found within the lumen of them. The presence rarely of fibrin in the wall of one or two vessels in the context of a periva…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…21; of neutrophils in perivascular and interstitial locale. If fibrin is present in the wall of venules, the diagnosis is leukocytoclastic vasculitis, not lupus erythematosus or Sweet’s syndrome. If no fibrin is present, which is the rule in ve…

Histologic Diagnosis of Inflammatory Skin Diseases

Pernio

Pernio Synonyms Dermatitis congelationis Chilblains Chilblain lupus Perniosis Erythema pernio Presentation stereotypical Age and sex Young persons usually with no predilection for either sex Distribution of lesions Fingers, toes, nose, and ears In…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent pigmented purpuric dermatitis

Persistent pigmented purpuric dermatitis Synonyms Pigmented purpuric dermatitis Progressive pigmentary dermatosis Progressive pigmented prupura Dermatosis pigmentaria progressiva Presentation stereotypical Age and sex Adults of both sexes; childre…

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