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Histologic Diagnosis of Inflammatory Skin Diseases

Images

….70.4A: Panniculitis, septal mostly + 10.70.4B: Extensive fibroplasia accompanied by scattered lymphocytes, the result being obliteration of some lobules + 10.70.4C + 10.70.4D = Nodular fasciitis ┬áThese changes represent a scarring p…

Differential Diagnosis in Dermatopathology

Discussions

…ulare, to wit, hardness that results from fibrosis. In short, fibroplasia is an important element of papular mucinosis, but it is not an accompaniment at all of granuloma annulare. Because granuloma annulare is truly granulomatous (histiocytes predom…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…be told by the number and depth of siderophages and by subtle fibroplasia in the upper part of the dermis positioned just beneath a thinned epidermis devoid of rete ridges. 10.78.9A: Perivascular dermatitis, lichenoid + 10.78.9B: Numerous e…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…a and acrosyringia. In time, peri-infundibular perifollicular fibroplasia strangled infundibulofollicular units progressively, obliterating them eventually, the result being permanent alopecia. In short, a diagnosis of lichen planopilaris can be made…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

…timately by scattered histiocytes. Even at a late stage, when fibroplasia is prominent, usually in the form of wiry bundles of collagen arranged in fascicles that interweave, neutrophils and “dust” of them pepper the lattice formed by the…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…cle Many lymphoid follicles joined by innumerable eosinophils Fibroplasia in the subcutaneous tissue Proliferation of small blood vessels lined by plump endothelial cells throughout the dermis Correlation clinicopathologic The nodules and tumors are…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…diffuse infiltrate of foam cells is accompanied by prominent fibroplasia. Reactional states, i.e., erythema nodosum leprosum, and reversal and downgrading reactions, are episodes acute that occur as a consequence of alterations in immunity that occu…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…plasma cells, and histiocytes in fat lobules Late Extensive fibroplasia in the subcutaneous fat and in the dermis Comment The term “erythema nodosum leprosum” is a misnomer that communicates misinformation to clinicians and histopathol…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…if any, fibrin in the wall of venules. At a much later stage, fibroplasia dominates, but even then there is a smattering of nuclear “dust” of neutrophils, although no fibrin is present at all in the wall of venules. 10.58.19A: Vascu…

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