Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…those of herpes, pox, and Coxsackie, but also of noninfectious diseases such as erythema multiforme, fixed drug eruption, and Mucha-Habermann disease. The term ballooning, if unmodified, is enigmatic because ballooning refers also to the appearance o…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cytes only, edema of the papillary dermis, and parakeratosis = Gianotti-Crosti disease The changes pictured are nearly indistinguishable from those of allergic contact dermatitis and nummular dermatitis. Therefore, a sure diagnosis of Gianotti-Crosti

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…may represent a second microscopic hallmark of Cowden’s disease in addition to facial tricholemmoma.” Starink TM, Meijer CJL, Brownstein MH. The cutaneous pathology of Cowden’s disease: new findings. J Cutan Pathol 1985;12:83&#8211…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cus of necrosis, and incipient parakeratosis = Mucha-Habermann disease, acute ¬†Neutrophils are seen often in early and fully developed lesions of Mucha-Habermann disease, particularly in zones of parakeratosis, as is the situation here. 10.66.3…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…is X, is the collective designation for a clinical spectrum of diseases which in the past even called Letterer-Siwe disease, Hand –Schuller-Christian disease, and eosinophilic granuloma of bone…” Weedon D. Skin Pathology, 2nd ed. Sy…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…ations in the presentation clinical and histopathologic of the disease. The combination of this diversity in presentation and the difficulty of excluding other blistering diseases made definitive diagnosis of acquired epidermolysis bullosa nearly imp…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…20;active” phase and up to 40 percent sensitive when the disease is in remission. But c-ANCA was found to be positive in low titers in other unrelated vasculitides, such as Takayasu disease and lymphomatoid vasculitis. In short, c-ANCA vasculit…