Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…now the nature of the infiltrate (e.g., lymphocytes mostly in Gianotti-Crosti disease or eosinophils prominently in the vesicular stage of incontinentia pigmenti); in the domain of ballooning vesicular dermatitis to appreciate distinctive cytopatholo…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ncidental finding in the context of a particular inflammatory disease such as in response to the “bite” of an insect on one hand and in response to treatment for cancer by agents chemotherapeutic, such as cytarabine, on the other. Figu…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…may represent a second microscopic hallmark of Cowden’s disease in addition to facial tricholemmoma.” Starink TM, Meijer CJL, Brownstein MH. The cutaneous pathology of Cowden’s disease: new findings. J Cutan Pathol 1985;12:83–…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…ons sometimes, and a perivascular infiltrate of lymphocytes = Gianotti-Crosti disease + Parakeratosis, individual necrotic keratocytes, lymphocytes, and sometimes histiocytes along the dermoepidermal interface, and a perivascular and periadnexal in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…one, and ballooned and necrotic keratocytes = Mucha-Habermann disease, acute That this lesion is recent in onset may be inferred from the presence of an entirely normal cornified layer, ballooned keratocytes, many individual necrotic keratocytes, and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…tratified squamous epithelia it could be assumed that HX is a disease in which these particular cells engage in pathologic proliferation. One could proceed further to imply that, if these conclusions are correct, HX represents a “Langerhans&#82…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ytes only, edema of the papillary dermis, and parakeratosis = Gianotti-Crosti disease The changes pictured are nearly indistinguishable from those of allergic contact dermatitis and nummular dermatitis. Therefore, a sure diagnosis of Gianotti-Crosti

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…DT, Gammon WR. Epidermolysis bullosa acquisita: an autoimmune disease with distinctive immunoultrastructural features. Cutis 1983 Dec;32:521–27. “These findings strongly suggest that autoantibodies that recognize human type VII collagen…