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Histologic Diagnosis of Inflammatory Skin Diseases

Lichen striatus

…ticular dermis Patchy lichenoid infiltrate of lymphocytes and histiocytes obscuring the dermoepidermal junction and, sometimes, the junction between adnexal epithelium and the dermis Some multinucleate histiocytes present in the papillary dermis Acan…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

…ndibula sometimes Lymphocytes in infundibular epidermis Foamy histiocytes and a few lymphocytes around infundibula and apocrine ducts sometimes Differential diagnosis histopathologic Plugging of infundibula may be seen in inflammatory diseases as un…

Histologic Diagnosis of Inflammatory Skin Diseases

Leishmaniasis

…loped Dense diffuse infiltrate of lymphocytes, plasma cells, histiocytes, and, occasionally, neutrophils throughout the reticular dermis and, at times, involving the septa of the subcutaneous fat Numerous gray-blue dots of Leishmania in the cytoplas…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…filtrates of lymphocytes accompanied by countless epithelioid histiocytes, many of them multinucleate, throughout the dermis and the subcutaneous fat to the base of the section of tissue Granulomatous inflammation striking throughout the dermis and t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ulomatous + 10.56.1B: Lymphocytes, plasma cells, and many histiocytes whose cytoplasm is filled with tiny round monomorphous basophilic organisms = Leishmaniasis, acute An American, European, or Asian who bears such a lesion usually has returned…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…mucin are abundant, in the center of palisades of epithelioid histiocytes. Rheumatoid nodule is a granulomatous panniculitis (and sometimes dermatitis) in which huge deposits of fibrin are surrounded by thin epithelioid histiocytes arrayed in a palis…

Differential Diagnosis in Dermatopathology

Discussions

…stereotypical” examples of xanthogranuloma display some histiocytes with “ground glass” cytoplasm and, in reverse, some “stereotypical” examples of granuloma exhibit histiocytes with foamy cytoplasm. These findings are y…

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