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Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarc…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

Lupus erythematosus Synonyms Lupus erythematodes Presentation stereotypical Age and sex Young adult women especially, but sometimes neonates and older persons of both sexes. Distribution of lesions Often localized to sun-exposed sites such as the fa…

Differential Diagnosis in Dermatopathology

Discussions

Lichen planus and lichenoid discoid lupus erythematosus have many findings histopathologic in common, among them hyperkeratosis of surface epidermis and plugs of cornified cells in infundibular epidermis; individual necrotic keratocytes; a lichenoid…

Differential Diagnosis in Dermatopathology

Discussions

Lichen simplex chronicus and hypertrophic lichen planus are both responses to persistent, vigorous rubbing. In fact, lichen simplex chronicus results entirely from rubbing what at first was normal skin, in contrast to hypertrophic lichen planus whic…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen striatus

Lichen striatus Synonyms Linear lichenoid dermatosis Presentation stereotypical Age and sex Mostly girls, but sometimes boys and young adults of both sexes Distribution of lesions Usually an extremity Arrangement of lesions Linear Individual lesions…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen nitidus

Lichen nitidus Presentation stereotypical Age and sex No predilection for age or sex, but most common in African-American children Distribution of lesions Penis, forearms, wrists, abdomen, and breasts especially; widespread rarely Arrangement of les…

Differential Diagnosis in Dermatopathology

Keratoacanthomatous verruca vulgaris vs. Verrucous keratoacanthoma

Papules on skin and mucous membranes that result from infection of keratinocytes by different types of papillomavirus and classified according to their silhouettes, to wit, papillated (verrucae vulgares on different sites such as volar skin, i.e., v…

Differential Diagnosis in Dermatopathology

Discussions

Lichen amyloidosis and colloid milium both result from deposits of homogeneous material in the dermis, but the composition chemical of them is as different as the appearance of them histopathologically. In both conditions, fibrocytes are affiliated…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

Psoriasis Presentation stereotypical Age and sex Persons of any age and of both sexes Distribution of lesions Localized, e.g., single papule or plaque, or universal, i.e., erythroderma; between these extremes, a preference for elbows and knees, scal…

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