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Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…but in tuberculoid leprosy they are joined by moderately dense infiltrates of lymphocytes. In lepromatous leprosy in reaction, dense infiltrates of neutrophils are intermingled with histiocytes. Vasculitis of small blood vessels is responsible for ul…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.64.1A: Nodular dermatitis, lymphocytes predominate + 10.64.1B: Small lymphocytes mostly = Lymphocytoma cutis ¬†At scanning magnification, the infiltrate of lymphocytes in the reticular dermis can be told to follow the course of p…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

Interstitial granulomatous dermatitis with arthritis Synonyms Interstitial granulomatous dermatitis with cutaneous cords and arthritis Rheumatoid papules Palisaded and neutrophilic granulomatous dermatitis Presentation stereotypical Age and sex Ad…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

“Lymphocytic vasculitis can be inferred unequivocally if there are infiltrates of lymphocytes in and around the walls of venules accompanied by fibrin deposition in their walls or lumens, or both.” Carlson JA, Mihm MC, Leboit PE. Cutan…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum

…ersect the granulomas Sparse superficial and deep perivascular infiltrate of lymphocytes in the reticular dermis Fully developed Fibrous septa widened markedly by a mixed-cell infiltrate of lymphocytes and histiocytes, some multinucleate; eosinophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.38.1A: Pustular dermatitis, infundibular + 10.38.1B: A hair containing hyphae in an abscess = Suppurative infundibulitis of dermatophytic cause (Majocchi’s granuloma) The hair was spewed into the dermis when an infundibul…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.27.1A: Pustular dermatitis, infundibular + 10.27.1B: Perivascular and interstitial infiltrate of many neutrophils and innumerable eosinophils in infundibula and sebaceous lobules = Eosinophilic pustular folliculitis Because eosi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…prominent + 10.29.2B: Perivascular and interstitial infiltrates of lymphocytes and neutrophils = Erysipelas The infiltrate of inflammatory cells in the section pictured is denser than usually is seen in erysipelas. Erysipelas is the qu…

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