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Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…pules, or plaques: Superficial perivascular and interstitial infiltrate of lymphocytes Vacuolar alteration along the dermoepidermal junction in company with a sprinkling of lymphocytes there Necrotic keratocytes scattered throughout the lower part o…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

…developed Superficial and deep perivascular and interstitial infiltrate of lymphocytes Histiocytes scattered interstitially, i.e., diffusely among collagen bundles and, in foci, in palisaded array, usually more marked in the lower than in the upper…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…se lepromatous leprosy is resistant to treatment; the diffuse infiltrate of foam cells is accompanied by prominent fibroplasia. Reactional states, i.e., erythema nodosum leprosum, and reversal and downgrading reactions, are episodes acute that occur…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…hocytic vasculitis can be inferred unequivocally if there are infiltrates of lymphocytes in and around the walls of venules accompanied by fibrin deposition in their walls or lumens, or both.” Carlson JA, Mihm MC, Leboit PE. Cutaneous lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…s, infundibular + 10.27.1B: Perivascular and interstitial infiltrate of many neutrophils and innumerable eosinophils in infundibula and sebaceous lobules = Eosinophilic pustular folliculitis Because eosinophils are more conspicuous than neutrophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum

…us fat widened by edema; sometimes fibrin present also Sparse infiltrate of neutrophils mostly around venules and in the interstitium of fibrous septa in the subcutaneous fat; tiny foci of suppuration in septa exceptionally Neutrophils scattered at t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.38.7B: Granulomatous inflammation and lymphoplasmacytic infiltrates around a zone of fibroplasias = Suppurative, granulomatous, and fibrosing dermatitis and panniculitis secondary to rupture of an infundibular cyst What is known, conventionally…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…: Perivascular and interstitial dermatitis + 10.29.1B: An infiltrate of lymphocytes, neutrophils, and eosinophils = Erysipelas Cellulitis, of which erysipelas is the stereotype, is an example of phlegmonous inflammation, i.e., one in which neutro…

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