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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…vasculitis. That is not the situation for vasculitis in which lymphocytes monopolize; vasculitis is not even suspected clinically. Moreover, no disease of the skin shows findings consistently of lymphocytic vasculitis. Predominance of lymphocytes in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…opathologically. The inflammatory cells in both conditions are lymphocytes. 10.42.4A: Perivascular dermatitis, interface, vacuolar + 10.42.4B: Lymphocytes along the dermoepidermal junction, necrotic keratocytes throughout the epidermis, hyp…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…interface dermatitis mediated by a monomorphous infiltrate of lymphocytes that tends to encircle venules of both the superficial and deep plexuses. Lymphocytes also obscure the dermoepidermal junction in conjunction with vacuolar alteration there, a…

Histologic Diagnosis of Inflammatory Skin Diseases

Post-inflammatory pigmentary alteration

…se that the melanoma is destroyed by inflammatory cells, i.e., lymphocytes, and the residuum is a thickened fibrotic papillary dermis within which are telangiectases, melanophages, and a sprinkling of lymphocytes. Those findings are seen clinically a…

Histologic Diagnosis of Inflammatory Skin Diseases

Alopecia areata, totalis, universalis

…Early Sparse superficial and deep perivascular infiltrate of lymphocytes Lymphocytes congregated especially around the bulb of follicles Follicles often in what seems to be the end of anagen or in early catagen; as a rule, nearly all the follicles…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…parakeratosis containing only tiny globules of serum 3. Few lymphocytes in association with prominent spongiosis 3. Many lymphocytes in company with slight spongiosis 4. Small lymphocytes in spongiotic foci 4. Small and sometimes large lymphocyt…

Differential Diagnosis in Dermatopathology

Discussions

…i.e., focal. In both diseases, intraepidermal infiltration by lymphocytes is accompanied by slight spongiosis, as always is the case when lymphocytes, whether inflammatory or neoplastic ones, permeate an epithelium. The epidermis in both conditions…

Differential Diagnosis in Dermatopathology

Discussions

…rivascular and interstitial mixed-cell infiltrates composed of lymphocytes and often of eosinophils, and may be typified further by the presence of some large lymphocytes, extravasated erythrocytes, edema of the papillary dermis, dilated venules and…

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