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Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

…canthoma showed statistically significant increased numbers of melanocytes compared with both normal skin and actinic keratosis. The number of melanocytes did not differ significantly between LCA and solar lentigo. In the era of dermoscopy, dermoscop…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidemic of Melanoma?

“Malignant melanoma of the skin is a major cancer in the young, working population, second in prevalence only to cancers of the testis in males in the 30-49-year-old range. Moreover, there is a recent increase in the incidence and mortality o…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythema Dyschromicum Perstans?

“During the year 1959–1960 in the Department of Dermatology of the Vargas Hospital in Caracas, we studied five adult patients with a peculiar new pigmentary disorder. . . . The skin eruption is characterized by numerous macules with a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

“In PLEVA, the more severe form, one observes vascular changes consisting of a pronounced mononuclear infiltrate around capillaries, with the capillaries showing endothelial swelling and permeation of their walls by the infiltrate. This usua…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

“Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, ro…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…histiocytes); no polygonal cells 4. Polygonal cells (abnormal melanocytes), but also abnormal melanocytes of different shapes 5. Melanophages rare; siderophages and lipophages common 5. Melanophages common; no siderophages or lipophages 6. Lymph…

Differential Diagnosis in Dermatopathology

Trichoblastoma, small nodular type vs. Trichoblastoma, large nodular type

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

Dermatology Practical & Conceptual

Yellow color upon dermatoscopy does not exclude melanoma!

In this issue, Rosendahl and colleagues report a case of non-choroidal melanoma that shows a strikingly unusual dermatoscopic aspect, namely, structureless yellow color. The authors correlate the yellow color to the presence of lipofuscin using tiss…

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