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Differential Diagnosis in Dermatopathology

Pagetoid Bowen’s disease vs. Extramammary Paget’s disease

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

Differential Diagnosis in Dermatopathology

Discussions

…ma in situ because some examples of that malignant neoplasm of melanocytes, especially those situated on the trunk and extremities, are characterized by abnormal pagetoid melanocytes distributed in pagetoid pattern in the epidermis and adnexal epithe…

Dermatology Practical & Conceptual

Melanoma and satellite blue papule

Abstract The colors that are seen in dermoscopy depend on the anatomic level of the skin at which the chromophores are seen. Blue color can be found in a variety of melanocytic and nonmelanocytic lesions. An 89-year-old man presented with a 3-year h…

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

…canthoma showed statistically significant increased numbers of melanocytes compared with both normal skin and actinic keratosis. The number of melanocytes did not differ significantly between LCA and solar lentigo. In the era of dermoscopy, dermoscop…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

“In PLEVA, the more severe form, one observes vascular changes consisting of a pronounced mononuclear infiltrate around capillaries, with the capillaries showing endothelial swelling and permeation of their walls by the infiltrate. This usua…

Dermatology Practical & Conceptual

Yellow color upon dermatoscopy does not exclude melanoma!

In this issue, Rosendahl and colleagues report a case of non-choroidal melanoma that shows a strikingly unusual dermatoscopic aspect, namely, structureless yellow color. The authors correlate the yellow color to the presence of lipofuscin using tiss…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…histiocytes); no polygonal cells 4. Polygonal cells (abnormal melanocytes), but also abnormal melanocytes of different shapes 5. Melanophages rare; siderophages and lipophages common 5. Melanophages common; no siderophages or lipophages 6. Lymph…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

“Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, ro…

Differential Diagnosis in Dermatopathology

Trichoblastoma, small nodular type vs. Trichoblastoma, large nodular type

Pigmented macules and patches mostly in the middle third of the face, vertically and horizontally, distributed symmetrically and occurring mainly in postpubescent women as a consequence of the combined effects of estrogen and ultraviolet light on me…

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