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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…dermatitis in skin damaged badly by sunlight Epithelial Mucinosis, e.g., Granular Cellularity, e.g., Alopecia mucinosa expression of mycosis fungoides Granular-cell schwannoma Angiolymphoid hyperplasia with eosinophils Fibrous papu…

Differential Diagnosis in Dermatopathology

Discussions

Changes histopathologic in both lupus erythematosus profundus and panniculitis-like T-cell lymphoma involve the subcutaneous fat especially where they have in common an infiltrate, in lobules and septa, comprised mostly of lymphocytes, fat necrosis…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…e lesions 12. No findings of discoid lupus erythematosus 13. Mucin common and often abundant in the dermis and/or the subcutaneous fat 13. Mucin uncommon and when present scant 14. Rim of sclerosis around some medium-sized vessels 14. No perivasc…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…minative cells sometimes 11. Papillary dermis not thickened; mucin not abundant there 11. Papillary dermis thickened at first by prominent granulation tissue; abundant mucin there early, fibrosis late 12. No infiltrates of inflammatory cells bene…

Differential Diagnosis in Dermatopathology

Infundibulo-folliculo-sebaceous cystic hamartoma vs. Steatocystoma

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…nuclei 5. Elastic fibers normal in number and appearance; no mucin accompanying 5. Elastic fibers altered at times and may be associated at times with increased mucin 6. Melanophages present often 6. No melanophages 7. Sparse lymphoplasmacytic…

Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

“Lupus erythematosus is a disorder associated with innumerable clinical signs and symptoms and a wide range of laboratory abnormalities; it shows a spectrum of varying prognoses ranging from a benign, solely cutaneous variant (localized disco…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Nodular fasciitis Malignant fibrous histiocytoma 1. Relatively symmetrical 1. Asymmetrical 2. Whorls and fascicles of mesenchymal cells 2. Fascicles of mesenchymal cells common, but no whorls of them 3. Nuclei of mesenchymal cells not crowde…

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