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Differential Diagnosis in Dermatopathology

Discussions

…periadnexal infiltrates of lymphocytes, abundant deposits of mucin in the reticular dermis and subcutaneous fat, vacuolar alteration along the dermoepidermal junction of an epidermis thinned focally, a smudged appearance of the dermoepidermal juncti…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…lesions 12. No findings of discoid lupus erythematosus 13. Mucin common and often abundant in the dermis and/or the subcutaneous fat 13. Mucin uncommon and when present scant 14. Rim of sclerosis around some medium-sized vessels 14. No perivascu…

Differential Diagnosis in Dermatopathology

Atrophic lichen planus vs. Atrophic discoid lupus erythematosus

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…flat endothelial cells at the periphery of some nodules 12. Mucin in the stroma sometimes 12. No mucin 13. Diffuse fibroplasia 13. Fibroplasia around lobules of endothelial cells at the periphery of a lesion 14. Thickened bundles of collagen wi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…differ from those of the tumid expression of discoid lupus erythematosus by the absence of copious amounts of mucin in the reticular dermis. What in times past was called “lymphocytic infiltration of Jessner” really is lupus tumidus….

Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…ally adnexal epithelium from the altered periadnexal dermis). Mucin is often abundant in the reticular dermis. The majority of patients who bear lesions of discoid lupus erythematosus show no systemic signs of lupus erythematosus. Under no circumstan…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…inative cells sometimes 11. Papillary dermis not thickened; mucin not abundant there 11. Papillary dermis thickened at first by prominent granulation tissue; abundant mucin there early, fibrosis late 12. No infiltrates of inflammatory cells benea…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…uclei 5. Elastic fibers normal in number and appearance; no mucin accompanying 5. Elastic fibers altered at times and may be associated at times with increased mucin 6. Melanophages present often 6. No melanophages 7. Sparse lymphoplasmacytic p…

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