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Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

Certain basic concepts that pertain to the method recommended here for diagnosis of inflammatory diseases of the skin and subcutaneous fat deserve mention. First, it is advantageous to examine sections of tissue, from the very outset, without refere…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…e the dense perivascular lymphocytic infiltrate with fibrinoid necrosis, which has been referred to as ‘lymphocytic vasculitis’, and the presence of basilar epidermal cytoid bodies and epidermal necrosis.” Daoud MS, Pittelkow MR. P…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.57.1A: Nodular dermatitis and panniculitis, granulomatous + 10.57.1B: Lymphocytes among dense infiltrates of slightly foamy histiocytes, some of them having a bluish cast + 10.57.1C + 10.57.1D = Leprosy, lepromatous…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

…the subcutis, there may be locular [sic] panniculitis and fat necrosis, together with massive hyaline necrosis, oedema, and haemorrhage. Diagnosis In its later stages the condition is distinguished from malignant histiocytosis by its chronic course…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…wall of small, medium-sized, and large vessels 7. Extensive necrosis en masse of adipocytes; karyorrhexis and karyolysis striking 7. Necrosis of adipocytes manifested mostly by karyorrhexis; karyolysis present, but subtle 8. Membanous fat necros…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

“Light and electron microscopical studies of erythema multiforme showed two types of tissue changes with bullae forming at a different location in each type. (a) Erythematous papular lesions revealed primarily dermal edema resulting in intra…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.32.1A: Perivascular dermatitis, interface, vacuolar + 10.32.1B: Predominance of lymphocytes, ballooned and individual necrotic keratocytes, and slight spongiosis = Erythema multiforme The normal cornified layer with its basket-w…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

Erythema multiforme Synonyms Herpes iris Ectodermis erosive pluriorificialis Erytheme polymorphe Erythema multiforme exsudativum minor (Erythema multiforme minor, Erythema multiforme simplex, Erythema papulosum [Papular erythema multiforme]) Present…

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