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Clinical Case Studies

Extensive Actinic Damage

INITIAL PRESENTATION A 67-year-old Caucasian male presented with severe photodamage of his face and scalp and a history of multiple nonmelanoma skin cancers. (Figure 1) The patient had been treated with radiation for adolescent acne vulgaris. One ye…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

“With the high power the hyaline is seen in very varied forms, which all show the same fuchsin red reaction. The first forms a section by itself; it comprises hyaline balls of different size, which lie free between the epithelial cells, and w…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

“Melanoma arising from lentigo maligna is preceded by or forms a part of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pigmented Lesions

Non-melanocytic lesions Inflammatory Post-inflammatory hyperpigmentation¬†(523, 649) Melanophages in number variable scattered in the papillary dermis, rarely in the upper part of the reticular dermis too. Melanin increased in amount in the epi…

Differential Diagnosis in Dermatopathology

Lymphocytoma cutis with lymphoid follicles vs. Follicular-cell lymphoma

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous T-cell Lymphoma?

“There has been a tendency in recent years to phase out the term ‘mycosis fungoides’ and replace it with peripheral cutaneous T-cell lymphoma (CTCL).” Santa Cruz DJ, Hurt MA. Neoplasms of the skin. In: Sternberg SS, ed. Dia…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

See Classification of Pigmented Lesions

…llary dermal type Nevoid hyperkeratosis of the nipple Benign neoplasms Solar lentigo, including lichen planus-like keratosis Seborrheic keratosis Malignant neoplasms Basal cell carcinoma, pigmented Solar keratosis, pigmented Melanocytic les…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dysplasia?

“Dysplasia (Ger.) n. A disturbance of formative activity.” Foster FP. Foster’s Encyclopedic Medical Dictionary. New York, NY: D. Appleton & Co., 1891:1378. “Dysplasia shares many cytologic features with cancer, and th…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

“In PLEVA, the more severe form, one observes vascular changes consisting of a pronounced mononuclear infiltrate around capillaries, with the capillaries showing endothelial swelling and permeation of their walls by the infiltrate. This usua…

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