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Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

…ations of Crohn’s disease, all of them characterized by neutrophils, range from urticaria to pyoderma gangrenosum, and include such conditions disparate as lesions of Sweet’s syndrome, hidradenitis suppurativa, and erythema nodosum (neutr…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Distinctive but Nonspecific Findings Using High Magnification

…n infundibular cyst that ruptured. “CHURG-STRAUSS GRANULOMA” Neutrophils, nuclear “dust” of neutrophils, and, sometimes, eosinophils in a discrete locus of degenerated collagen in the reticular dermis, histiocytes in palisaded array at the periphery…

Differential Diagnosis in Dermatopathology

Discussions

…serum. There are hypogranulosis, pallor of the epidermis, and neutrophils in the cornified layer and beneath it in viable epithelium. An increased number of mitotic figures can be noted above the epidermal basal layer. Despite so many shared findings…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…is seen to begin with a sparse infiltrate of lymphocytes and neutrophils around venules of the superficial plexus, neutrophils and nuclear “dust” of neutrophils sprinkled in the uppermost reaches of the dermis and sometimes along the der…

Histologic Diagnosis of Inflammatory Skin Diseases

Erysipelas

…lar and interstitial mixed-cell infiltrate composed mostly of neutrophils, but also of lymphocytes and, episodically, of eosinophils around venules Widely dilated venules and lymphatics in the upper part of the dermis Edema of the papillary dermis F…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…itis, granulomatous and suppurative + 10.35.1B: Countless neutrophils in the interstitium + 10.35.1C + 10.35.1D = Factitious dermatitis Each focus of fibrin represents a site where a needle penetrated the skin and around each of thos…

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