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Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

…Pattern Analysis, 1978: superficial perivascular dermatitis + spongiosis + psoriasiform hyperplasia = spongiotic psoriasiform dermatitis (allergic contact or nummular dermatitis, fully developed). Figure 5.4 Contents of Histologic Diagnosis of Inf…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…s. Histopathologically, the urticarial lesions were marked by spongiosis with formation of intraepidermal blisters, a lichenoid infiltrate of histiocytes, and vasculitis of small vessels. A few neutrophils, eosinophils, and extravasated erythrocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…cantholytic dyskeratosis is a clue to Grover’s disease. Spongiosis in association with focal acantholytic dyskeratosis is a clue to Grover’s disease. Cause and mechanism The cause is unknown, but in some instances Grover’s disease…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….42.1B: Lymphocytes along the dermoepidermal junction, slight spongiosis, and necrotic keratocytes in a thin epidermis = Graft-versus-host disease Sometimes it is difficult to differentiate graft-versus-host disease from erythema multiforme on ground…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…and scale-crusts are situated atop an epidermis punctuated by spongiosis, and in ichthyosis linearis circumflexa, mounds of parakeratosis also are situated above loci of spongiosis. In short, bullous congenital ichthyosiform erythroderma and variants…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…bly represent findings at the periphery of the lesion because spongiosis in the center of it usually is more prominent, sometimes even eventuating in intraepidermal vesiculation. 10.41.3A: Perivascular dermatitis, spongiotic + 10.41.3B: Lym…

Dermatology Practical & Conceptual

Saved by step sections: an unusual presentation of basal cell carcinoma

…djacent epidermis depicted irregular acanthosis and prominent spongiosis with inflammatory cells in exocytosis; superficial and mid-dermis presented a dense inflammatory infiltrate composed mainly of lymphocytes. Step sections were ordered because sk…

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