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Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

Grover’s disease Synonyms Transient acantholytic dermatosis Transitory acantholytic dermatosis Benign papular acantholytic dermatosis Persistent acantholytic dermatosis Presentation stereotypical Age and sex Middle-aged and elderly adults, h…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.42.1A: Perivascular dermatitis, interface, vacuolar + 10.42.1B: Lymphocytes along the dermoepidermal junction, slight spongiosis, and necrotic keratocytes in a thin epidermis = Graft-versus-host disease Sometimes it is difficult…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…and scale-crusts are situated atop an epidermis punctuated by spongiosis, and in ichthyosis linearis circumflexa, mounds of parakeratosis also are situated above loci of spongiosis. In short, bullous congenital ichthyosiform erythroderma and variant…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.41.1A: Perivascular dermatitis, spongiotic psoriasiform + 10.41.1B: Lymphocytes only, edema of the papillary dermis, and parakeratosis = Gianotti-Crosti disease The changes pictured are nearly indistinguishable from those of all…

Dermatology Practical & Conceptual

Saved by step sections: an unusual presentation of basal cell carcinoma

Abstract Background: Basal cell carcinoma usually occurs in sun exposed areas of older male individuals. Objectives: To emphasize the importance of histological step sections in the pursuit of the correct diagnosis when microscopic findings do not…

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