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Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

“This latter category, where the cells are destroyed during the course of the process, I proposed a few years ago to designate by a term which has been employed to express disease generally by K. H. Schultz, viz., necrobiosis. Necrobiosis is…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

Erythema nodosum leprosum Features clinical Red nodules or plaques that may develop anywhere but especially the thighs and legs Findings histopathologic Early Suppurative lobular panniculitis, focal at first and then diffuse Patchy zones of extensi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.47.1A: Perivascular dermatitis, interface, patchy lichenoid + 10.47.1B: Keratocytes with steel-gray nuclei, “margination” of chromatin, ballooned cytoplasm, and multinucleate and necrotic keratocytes = Infection by h…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

An arteritis in the subcutaneous fat manifested clinically at first by one or more red nodules that, in time, become ulcerated and heal with scars, usually on the posterior aspect of the legs of short, thick-legged women. No cause is usually found,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

“Retinopathy, neuropathy and nephropathy of the diabetic syndrome are well known. The same or similar pathological process in the dermis should be called dermopathy. Dermopathy with its disease of small blood vessels, supports and extends Bu…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg

The patient A 61-year-old woman presented herself with a chronic and widespread eruption of erythematous papules, pustules, ulcers, and hyperpigmented scars (Figures 1A-E). She had a history of rheumatoid arthritis. Figures 1A-E. Clinical appeara…

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