Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

…hemiatrophy], fasciitis with eosinophilia, tryptophan-myalgia syndrome) and progressive systemic sclerosis (acrosclerosis, diffuse systemic sclerosis, toxic oil syndrome) Deficiency diseases (including pellagra, acrodermatitis enteropathica, necroly…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Anagen Effluvium?

“The follicle tends to respond in an all or none fashion with the notable exception of its response to cancer chemotherapy agents. This is the only known instance in which hair is lost follicles which continue in their growing phase without b…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphedema

Lymphedema Presentation stereotypical Age and sex Adults usually, women more than men Distribution of lesions Distal extremities, legs more than arms; genitalia episodically Arrangement of lesions Diffuse involvement of parts, e.g., elephantiasis In…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

See Fig. 5.218 A&B. Figure 5.218 Vasculitis. A. Small vessel. B. Large vessel. Before a reasoned and reasonable method for diagnosis histopathologic of vasculitis in skin and subcutaneous fat can be formulated, a definition of vasculitis must…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…c LE II. Subacute cutaneous LE A. Papulosquamous B. Annular C. Syndromes commonly exhibiting similar morphology 1. Neonatal LE 2. Complement deficiency syndrome III. Acute cutaneous LE (systemic LE with skin lesions) localized or generalized erythema…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…eminds by way of analogy (albeit vaguely) of trytophan-myalgia syndrome, toxic oil syndrome, and Shulman’s syndrome, inflammatory conditions all. Last, if a histopathologist is stymied by particular findings met with in sections of tissue, repr…

Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…bones, exophthalmos, and diabetes insipidus (Christian’s syndrome). Arch Intern Med 1928;42:611. Rowland RS. Christian’s syndrome and lipoid cell hyperplasias of the reticulo-endothelial system. Arch Intern Med 1929;2:1277–99. Scott RB. L…