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Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…prove eventually to be something other than true inflammatory diseases, they resemble them nonetheless. Letterer-Siwe disease, which is one characteristic expression of histiocytosis X, illustrates the problem well. Is it truly a “granulomatos…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…bundant amphophilic cytoplasm = Histiocytosis X (Letterer-Siwe disease) Beneath the bandlike infiltrate of abnormal Langerhans” cells is a mixed infiltrate of inflammatory cells, findings repeatable in Letterer-Siwe disease and Hand-Schüller-Ch…

Differential Diagnosis in Dermatopathology

Discussions

…wer patients have a fatal outcome from Hand-Schüller-Christian disease than from Letterer-Siwe disease. Eosinophilic granuloma typically consists of a solitary lesion in a bone; hardly ever is the skin involved, and the disease almost never is fatal….

Differential Diagnosis in Dermatopathology

Mycosis fungoides, plaque vs. Histiocytosis X, plaque

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…s histiocytoses   Langerhans cell histiocytosis (CD1a+, S100+) Letterer-Siwe disease Hand-Sch?ller-Christian disease Eosinophilic granuloma Congenital self-healing reticulohistiocytosis Non-Langerhans cell histiocytoses Overlap disorders (CD1a-, S100…

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