Search Results for: letterer-siwe disease

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Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…ltrates of abnormal Langerhans’ cells, neutrophils, eosinophils, lymphocytes, and plasma cells, (lichenoid in LettererSiwe disease and nodular and diffuse in Hand-Schüller-Christian disease) Abnormal Langerhans’ cells with a large pale…

Langerhans cell histiocytosis-a case report

Langerhans cell histiocytosis-a case report

…and Lichtenstein in 1944, some clinical syndromes had been independently described and later named eponymously [4]. LettererSiwe disease usually occurs in children under one year of age, has a poor prognosis and manifests itself as fever and skin…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…ven if they prove eventually to be something other than true inflammatory diseases, they resemble them nonetheless. LettererSiwe disease, which is one characteristic expression of histiocytosis X, illustrates the problem well. Is it truly a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…large pale nuclei and abundant amphophilic cytoplasm associated with a mix of inflammatory cells = Histiocytosis X (LettererSiwe disease) The diagnosis histopathologic depends on recognition of the distinctive abnormal Langerhans” cells….

Differential Diagnosis in Dermatopathology

Mycosis fungoides, plaque vs. Histiocytosis X, plaque

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that…

Differential Diagnosis in Dermatopathology

Discussions

…(on fresh frozen tissue only), whereas the neoplastic cells of histiocytosis X are negative with these antibodies. LettererSiwe disease, Hand-Schüller-Christian disease, and eosinophilic granuloma are names given to different manifestations…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…clear phagocyte and dendritic cell systems The cutaneous histiocytoses Langerhans cell histiocytosis (CD1a+, S100+) LettererSiwe disease Hand-Sch?ller-Christian disease Eosinophilic granuloma Congenital self-healing reticulohistiocytosis…

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