Search Results for: letterer-siwe disease

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Histologic Diagnosis of Inflammatory Skin Diseases

Histiocytosis X

…otracted, if not treated; sometimes fatal Variations clinical LettererSiwe’s disease consists of reddish-brown or purpuric often slightly scaly papules and plaques on the scalp, face, trunk, and buttocks; internal organs often are involved, e….

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…litary lesions to disseminated, multisystem, life-threatening disease. Previous to the unifying concept advanced by Jaffe and Lichtenstein in 1944, some clinical syndromes had been independently described and later named eponymously [4]. Letterer-Siw…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

…prove eventually to be something other than true inflammatory diseases, they resemble them nonetheless. LettererSiwe disease, which is one characteristic expression of histiocytosis X, illustrates the problem well. Is it truly a “granulomatosi…

Histologic Diagnosis of Inflammatory Skin Diseases


…ssociated with a mix of inflammatory cells = Histiocytosis X (LettererSiwe disease) The diagnosis histopathologic depends on recognition of the distinctive abnormal Langerhans” cells. Numerous erythrocytes extravasated in the upper part of the…

Differential Diagnosis in Dermatopathology


…cells of histiocytosis X are negative with these antibodies. LettererSiwe disease, Hand-Schüller-Christian disease, and eosinophilic granuloma are names given to different manifestations clinical of infiltration by neoplastic Langerhans’ cell…

Differential Diagnosis in Dermatopathology

Mycosis fungoides, plaque vs. Histiocytosis X, plaque

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology


…histiocytoses   Langerhans cell histiocytosis (CD1a+, S100+) LettererSiwe disease Hand-Sch?ller-Christian disease Eosinophilic granuloma Congenital self-healing reticulohistiocytosis Non-Langerhans cell histiocytoses Overlap disorders (CD1a-, S100-…

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