Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…e xanthogranuloma usually presents itself in a child as one or several yellow nodules, but without bullae; Darier’s sign cannot be elicited. Spitz’s nevus, especially in children, may be expressed as a pink or orange papule incapable of u…

Histologic Diagnosis of Inflammatory Skin Diseases


…papules and nodules, but it is associated with Darier’s sign, i.e., urtication of a lesion in response to rubbing it. Histiocytosis X is accompanied by purpuric papules. Spitz’s nevus tends to be a solitary pink or orange, but not yellow…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…province of melanoma alone, they being found in various nevi, Spitz’s nevus being the prime example of that, so, too, it is for atypical lymphocytes, which not only are seen in lymphomas, but may be met with in a lymphomatoid inflammatory proc…

Differential Diagnosis in Dermatopathology

Xanthogranuloma vs. Reticulohistiocytic granuloma

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology


…ate when they are rubbed, a phenomenon known as Darier’s sign. A solitary lesion of juvenile xanthogranuloma may be confused clinically with a Spitz’s nevus. Each may be an orange, smooth-surfaced papule. In contrast to the expression in…

Histologic Diagnosis of Inflammatory Skin Diseases


Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…or cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO: CV Mosby Co….