Differential Diagnosis in Dermatopathology

Discussions

…histopathologically cribriform (trichoepithelioma), columnar (desmoplastic trichoepithelioma), retiform, racemiform, and adamantenoid. There also are types several predicated on clinico-pathologic correlation of trichoblastic carcinoma, those being t…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…hologic alone, to distinguish some hyperplasias, e.g., “desmoplastic tricholemmoma” and “inverted follicular keratosis” (both of these being endophytic verruca vulgaris) from a neoplasm, sometimes even a malignant one. Because…

Differential Diagnosis in Dermatopathology

Metastatic carcinoma from a breast vs. Morpheiform basal-cell carcinoma

…a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may devel…

Differential Diagnosis in Dermatopathology

Discussions

…hest. Syringomas tend to affect women more commonly than men. Desmoplastic trichoepithelioma also must be distinguished histopathologically from metastatic carcinoma of the breast to the skin and from morpheiform basal-cell carcinoma. The aspect cruc…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…ual dermatofibroma and may ulcerate in the absence of trauma. Desmoplastic melanoma is more asymmetrical, subtly variegate in color, and unaffiliated with a “dimple sign.” Spitz’s nevus may be red, orange, or pink, as well as brown…

Differential Diagnosis in Dermatopathology

Images

Dermatofibroma Desmoplastic Spitz’s nevus…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma Desmoplastic Spitz’s nevus 1. Acanthotic epidermis often associated with induction of folliculo-sebaceous units 1. Little or no acanthosis; no induction of folliculo-sebaceous units 2. Epidermis often thinned above the cen…