Differential Diagnosis in Dermatopathology

Apocrine (clear-cell) hidradenoma vs. Eccrine (poroid) hidradenoma

…melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nod…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

Kimura’s disease Synonyms Eosinophilic lymphofolliculitis Presentation stereotypical Age and sex Young men, especially Asians Distribution of lesions Head, neck, and trunk Individual lesions Firm nodules and tumors, some gigantic, above which…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

ABCDEs?

…t can be classified and named eponymically for Unna, Miescher, Spitz, Clark, and Reed. Clark’s nevi, by far the most common melanocytic nevi in man, usually are tiny, about 3 mm in greatest diameter, and are characterized by symmetry, sharp cir…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…these two diseases may overlap.” Romero RW, Nesbitt LT, Reed RJ. Unusual variants of lupus erythematosus or lichen planus. Arch Dermatol 1977;113:741–48. “The overlap syndrome, lichen planus/lupus erythematosus, refers to a heterogenous

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

Urticaria pigmentosa Synonyms Mastocytosis Presentation stereotypical Age and sex All ages and both sexes, but mostly nodules and blisters in infants and children, and mostly macules and papules in adults Distribution of lesions Localized or widespr…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphomatoid papulosis

…with large pleomorphic roundish nuclei and prominent nucleoli surrounded by abundant amphophilic cytoplasm Binucleate abnormal lymphocytes that resemble Reed-Sternberg’s cells and multinucleate abnormal lymphocytes sometimes present Some abnor…

Dermatology Practical & Conceptual

Pigmented Lesions

…elanocytes are oval/spindle and monomorphic, and the cytoplasm sports striking dendrites responsible for the melanin abundant in melanocytes, keratocytes, and macrophages. Yet to be classified Clark-like (582, 584) Spitz-like (352, 585) Reed-lik…