Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

…part from the fact that all of them are neoplasms composed of melanocytes, they have nothing in common! Lentigo maligna is a synonym for a flat lesion of melanoma (melanoma in situ) situated on skin that has been damaged badly by the effects of ultra…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidemic of Melanoma?

…ts development. It makes no sense for a malignant neoplasm of melanocytes of noninfectious cause to suddenly assume proportions epidemic. It makes good sense, however, to explain that purported phenomenon on the basis of greatly enhanced capability t…

Dermatology Practical & Conceptual

Nail matrix melanoma: consecutive cases in a general practice

…a doctor’s surgery office and thought the photo looked like her teacher’s thumb. At first he was somewhat sceptical, but she persisted until he saw his GP, who referred him to a specialized melanoma centre. They, in turn, referred him to…

Histologic Diagnosis of Inflammatory Skin Diseases

Vitiligo

…rotracted usually, but repigmentation occurring at times from melanocytes situated in infundibula Variations clinical Association, episodically, with alopecia areata, Hashimoto’s thyroiditis, diabetes mellitus, Addison’s disease, lupus e…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Differential Diagnosis in Dermatopathology

Discussions

…amphophilic cytoplasm. The cytoplasm may extend in long fish-like tails, a shape that has prompted the comparison of clusters of those cells to “schools of fish.” A cleft often surrounds each of the distinctive polygonal melanocytes. Whe…