Dermatology Practical & Conceptual

Nail matrix melanoma: consecutive cases in a general practice

…men of nail matrix from Case 1. It is difficult to distinguish melanocytes from keratinocytes. [Copyright: ©2012 Rosendahl et al.] Figure 5. High power micrograph of the H&E stained section shown in Figure 4 shows plump pale melanocytes at the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Precursor Lesions of Melanoma?

“Precursors of melanoma are lesions that are benign per se but have the potential of turning malignant and thus giving rise to melanoma. Two such entities are recognized: (1) atypical nevomelanocytic proliferation, and (2) congenital nevomela…

Histologic Diagnosis of Inflammatory Skin Diseases

Vitiligo

…the lower half of the epidermis Normal complement of epidermal melanocytes Fully developed Sparse superficial perivascular infiltrate of lymphocytes Melanocytes at the dermoepidermal junction decreased markedly in number Melanin in the epidermis de…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Differential Diagnosis in Dermatopathology

Discussions

…plasia longstanding and of effects of the process on epidermal melanocytes. A Spitz’s nevus, like some other kinds of melanocytic nevi, evolves in sequential fashion. It begins with proliferation of abnormal melanocytes in the epidermis (juncti…