Differential Diagnosis in Dermatopathology

Differential Diagnosis

Spitz’s Nevus, Compound Type Melanoma 1. Symmetric 1. Asymmetric 2. Sharp circumscription 2. Poor circumscription 3. Maturation of melanocytes (decrease in size of aggregations and of nuclei) with descent progressive 3. No maturation w…

Differential Diagnosis in Dermatopathology

Images

Spitz’s Nevus, Compound Type Melanoma…

Differential Diagnosis in Dermatopathology

Images

Dermatofibroma Desmoplastic Spitz’s nevus

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphadenosis benigna cutis

…cal Lymphoma may be indistinguishable. When the breast is the site affected, primary carcinoma must be considered. Tick “bite” and assaults by other arthropods may be identical. Spitz’s nevus often presents itself as a pink, red, o…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…absence of trauma. Desmoplastic melanoma is more asymmetrical, subtly variegate in color, and unaffiliated with a “dimple sign.” Spitz’s nevus may be red, orange, or pink, as well as brown or black, but it is not firm unless it is w…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma Desmoplastic Spitz’s nevus 1. Acanthotic epidermis often associated with induction of folliculo-sebaceous units 1. Little or no acanthosis; no induction of folliculo-sebaceous units 2. Epidermis often thinned above the cen…

Differential Diagnosis in Dermatopathology

Discussions

A proliferation of keratocytes that simulates squamous-cell carcinoma and authentic squamous-cell carcinoma itself have findings histopathologic in common, including epithelial cells that cornify, nuclei of epithelial cells that are not entirely typ…