Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous Horn?

“Cutaneous horns may complicate solar keratoses, viral warts, seborrheic warts, squamous cell carcinomas, lichenoid keratoses, and basal cell carcinomas.” McKee PH. Tumors of the surface epithelium. In: Pathology of the Skin with Clinic…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…utaraldehyde rather than in formalin. That fixative prepares a specimen for analysis by both light and electron microscopy. In sum and in short, if a biopsy specimen is not taken properly and sections from it are not prepared well, even an Unna is un…

Histologic Diagnosis of Inflammatory Skin Diseases

Keratosis pilaris/Lichen spinulosus

…by the clinical lectures of Dr Biett, physician to the Hopital St Louis, Paris. Translated from the French with notes. Philadelphia: Carey, Lea & Carey, 1829. Radcliffe-Crocker H. Diseases of the Skin. London: 1888:228, 298. Unna PG. Infectious i…

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Method for Surgery

…t it is a highly circumscribed one confined to what clinically seem to be benign, mostly exophytic growths such as warts, skin tags, seborrheic keratoses, and the melanocytic nevi of Unna and Miescher types. Those banal lesions may be removed in cosm…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…absence of trauma. Desmoplastic melanoma is more asymmetrical, subtly variegate in color, and unaffiliated with a “dimple sign.” Spitz’s nevus may be red, orange, or pink, as well as brown or black, but it is not firm unless it is w…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…matosus: a cutaneous marker for a distinct lupus erythematosus subset. Arch Dermatol 1979;115:1409–15. Srivastava M, Rencic A, Diglio G, et al. Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. Arch Dermatol 2003;139(1):45-49. Unna PG. Ule…

Histologic Diagnosis of Inflammatory Skin Diseases

…which deposits of a fibrillary protein (amyloid) appear in the skin as macules, papules, and nodules consequent to the effects of local factors, or as patches (which may be purpuric), plaques, nodules, and tumors as a result of a systemic disease lik…

Histologic Diagnosis of Inflammatory Skin Diseases

Androgenetic (common) alopecia

Androgenetic (common) alopecia Presentation stereotypical Age and sex Adults, men mostly and more extensively than in women Distribution of lesions Symmetric on the scalp, particularly the frontoparietal region and the vertex of men and the midporti…