Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

…f karyophagocytosis and are devoid of large numbers of plasma cells. Histiocytosis X is constituted of abnormal Langerhanscells with distinctive attributes cytopathologic, namely, reniform nuclei and abundant amphophilic cytoplasm; there is n…

Histologic Diagnosis of Inflammatory Skin Diseases


…Niessen FB, Schalkwijk J, Vos H, Timens W. Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells. J Pathol 2004;202(1):121-29. Rahban SR, Garner WL. Fibroproliferative scars. Clin Plast Surg 2003;30:77-89….

Histologic Diagnosis of Inflammatory Skin Diseases

Borreliosis (erythema migrans)

…linska D, Bartak P, Hercogova J, et al. Electronmicroscopy of Langerhans cells and Borrelia burgdorferi in Lyme disease patients. Zentralbl Bakteriol 1994;280:348-59. Kenneth B. Liegner, M.D., P.C. Lyme borreliosis: The sensible pursuit of answers. J…

Differential Diagnosis in Dermatopathology


…fungoides, the collections in the epidermis consist mostly of Langerhanscells joined by a few keratocytes and lymphocytes. Although the keratocytes in those foci have begun to separate, they are seen to be attached still to one another by int…

Histologic Diagnosis of Inflammatory Skin Diseases


…enables clearance from the dermis of fluids, macromolecules, cells, and foreign material. The twin roles of the lymphatic network as a conduit for Langerhanscells and as an exit for macromolecules such as lipids, proteins, and immune complex…

Histologic Diagnosis of Inflammatory Skin Diseases

Gianotti-Crosti disease

…one another, if only partially, thereby causing those spinous cells to assume a stellate shape, and the “pale cells” devoid of intercellular bridges and stellate shape, they being Langerhanscells. Spongiotic simulation of Pautrier…

Histologic Diagnosis of Inflammatory Skin Diseases


…logic, namely, erythema annulare centrifugum). Collections of cells in the epidermis that vaguely resemble those in mycosis fungoides named for Pautrier actually consist here mostly of keratocytes and Langerhans”, they being joined by a few lym…

Dermatology Practical & Conceptual

European dermatology: great past-no future?

…I was a resident, we did not really feel that the function of Langerhans cells would ever be unraveled, that melanoma could ever be defeated, and that the cause of genodermatoses would ever be pinpointed. Today, we are very close to all these answers…