Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

“A malignant neoplasm, i.e., cancer, exhibits the properties of: 1. invasion when its cells infiltrate the surrounding normal tissue; and 2. metastasis, the capacity of cancer cells to spread and grow at sites distant from the origin of the n…

Differential Diagnosis in Dermatopathology

Discussions

…remarkable feature of nuclei of fibrocytes in some collagenous nevi is their startling atypia. Connective tissue nevi of the skin, in general, are hamartomas that consist of alterations of one or more components of the extracellular matrix: collagen,…

Differential Diagnosis in Dermatopathology

Discussions

Epidermolytic hyperkeratosis and a plane wart share several findings histopathologic, among them being a papillated and thickened epidermis, hypergranulosis, and cells with pale cytoplasm within the epidermis. The terms “epidermolytic hyperker…

Differential Diagnosis in Dermatopathology

Epidermolytic hyperkeratosis vs. Plane wart

An inflammatory process in which lesions present themselves clinically as red macules and subtle scaly papules. They soon become so confluent that there is widespread redness and scaling punctuated by islands of skin that ostensibly are spared and b…