Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…ells, i.e., germinative cells, within embryonic epidermis. In plantar skin, Merkel cells have been identified as early as the 12th week of gestation. In the 16th week, Merkel cells make their appearance first in surface epithelium of the fingertips a…

Histologic Diagnosis of Inflammatory Skin Diseases

Topography and Regional Variation

…ects caused by infections in utero, e.g., rubella. Palmar and plantar skin is typified histologically by a thick cornified and granular layer, a prominent undulate pattern of epidermal rete ridges and dermal papillae, numerous eccrine units and nerve…

Differential Diagnosis in Dermatopathology

Epidermolytic hyperkeratosis vs. Plane wart

An inflammatory process in which lesions present themselves clinically as red macules and subtle scaly papules. They soon become so confluent that there is widespread redness and scaling punctuated by islands of skin that ostensibly are spared and b…

Differential Diagnosis in Dermatopathology

Discussions

…ulgares exhibit digitated epidermal hyperplasia. In contrast, plantar warts are mostly endophytic, as a result of pressure exerted upon them by walking. The papillomavirus responsible for warts also seems to be capable of causing squamous-cell carcin…

Dermatology Practical & Conceptual

Dermoscopic clues to diagnose acantholytic dyskeratosis

…uch as cutaneous squamous-cell carcinoma, verrucal keratosis, plantar hyperkeratosis, hair follicle changes, panniculitis, and photosensitivity [2], along with widespread eruptions with histologic features of acantholytic dyskeratosis [3]. Acantholyt…