Dermatology Practical & Conceptual

Papillary adenocarcinoma in situ of the skin: report of four cases

…00); (C) High power view showing the presence of necrosis and peripheral myoepithelial cell layer (H&E, x400). [Copyright: ©2014 Chen et al.] Figure 3. Case 3, papillary adenocarcinoma in situ. Immunocytochemical stain for P63 (A, x400) and Ki6…

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

…pustules. It rapidly extends to become ulcers marked at their periphery by boggy tissue. The skin disease is associated commonly with inflammatory bowel disease, especially ulcerative colitis, and sometimes with rheumatoid arthritis, paraproteinemia,…

Differential Diagnosis in Dermatopathology

Discussions

…d epidermal basement membrane in discoid lupus erythematosus, peri-infundibular fibrosis in lichen planus, and melanophages situated beneath a thickened basement membrane in discoid lupus erythematosus, but scattered throughout a fibrotic papillary d…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…phic lichen planus 1. Granular zone thickened, but not with periodicity and in wedge shape 1. Granular zone often thickened focally at nearly periodic intervals and in wedge shape, especially in infundibula 2. Infundibula, when acanthotic, not ma…

Differential Diagnosis in Dermatopathology

Discussions

…anus share several findings histopathologic, among them being perivascular, peri-infundibular, and perifollicular infiltrates of lymphocytes, vacuolar alteration at the junction between infundibula and dermis, infundibula plugged by orthokeratotic co…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…dermis as a rule 4. Moderately dense superficial and deep, perivascular and interstitial, mixed-cell infiltrate; sometimes superficial only 4. Sparse superficial and deep perivascular and predominantly interstitial mixed-cell infiltrate; sometimes…

Differential Diagnosis in Dermatopathology

Discussions

…of the dermis and the epidermis. Both are characterized by a perivascular infiltrate of lymphocytes and histiocytes, lymphocytes and vacuolar alteration at the dermoepidermal junction, necrotic keratocytes, and parakeratosis. Lymphocytes usually pre…

Differential Diagnosis in Dermatopathology

Discussions

…ch may show both intra- and subepidermal vesiculation, or the periphery, which may house edema in the papillary dermis and exhibit no vesiculation). The usual appearance histopathologic of an entire lesion of a typical vesicular reaction to an assaul…

Differential Diagnosis in Dermatopathology

Discussions

…in common. Both may be associated with a superficial and deep perivascular and lichenoid infiltrate of mononuclear cells, acanthosis, parakeratosis, and erosion or ulceration. Erythrocytes are extravasated in the dermis, neutrophils and lymphocytes m…

Histologic Diagnosis of Inflammatory Skin Diseases

Seborrheic dermatitis

…duration. Findings histopathologic Early Sparse superficial perivascular infiltrate of lymphocytes sometimes accompanied by a few neutrophils Slight edema of the papillary dermis Spongiosis in surface and infundibular epidermis Scale-crusts, especi…