Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

Lupus erythematosus Synonyms Lupus erythematodes Presentation stereotypical Age and sex Young adult women especially, but sometimes neonates and older persons of both sexes. Distribution of lesions Often localized to sun-exposed sites such as the fa…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…in the epidermis at times 4. Individually necrotic keratocytes sometimes; no confluent necrosis 5. Intra-epidermal vesicles or pustules often 5. No intra-epidermal vesicles or pustules 6. Abnormal lymphocytes scattered as solitary units in the ep…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema figuratum

…t chronique) et de quelques eruptiones analogues. Ann Dermatol Syph 1916;6:57–76. Clark WH, Mihm MC, Reed RJ, Ainsworth AM. The lymphocytic infiltrates of the skin. The lymphocytic infiltrates of the skin. Hum Pathol 1974;5:25. Harrison PV. The annul…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

Destombes-Rosai-Dorfman disease Synonyms Rosai-Dorfman disease Rosai-Dorfman histiocytosis Sinus histiocytosis with massive lymphadenopathy Presentation stereotypical Age and sex Usually in males under 25 years of age Distribution of lesions Localiz…

Differential Diagnosis in Dermatopathology

Lymphomatoid papulosis vs. Mycosis fungoides, plaque

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Discussions

…large lymphocytes with a markedly cerebriform outline. In the second pattern, atypical lymphocytes resemble those of Reed-Sternberg cells of Hodgkin’s cells. In one pattern the infiltrate is mixed, consisting of small lymphocytes, plasma cells