Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Junctional Activity and Active Junctional Nevus?

…tes with progressive descent into the dermis (both in terms of size of nests and size of nuclei) and nuclei of melanocytes monomorphic in nevi (except for Spitz nevi and ancient Mieschers nevi), in contrast to nuclei of melanocytes in melanoma…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Satellite, in Transit, Regional, and Distant Metastases?

sentinel node biopsy was a useless exercise and doomed to the same ash-heap on which is strewn so many other egregious misconceptions about therapy for melanoma, ranging from amputation of limbs to the Miescher therapy with grenz rays for “len…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Normal, Typical, Ordinary, Banal, and Common Nevus?

…n not contrasting (common versus uncommon) but, paradoxically, so-called dysplastic (Clark’s) nevus is more common by far than any so-called common nevus. Other melanocytic nevi, such as Unna’s, Mieschers, and Spitz’s, also a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…hair has been twisted back and forth. It does not, in itself, signify trichotillomania; sometimes patients twist a hair, to and fro, that emanates from a Mieschers nevus, for example, that hair inevitably showing evidence of trichomalacia. Th…

Dermatology Practical & Conceptual

The so-called dysplastic nevus is not dysplastic at all

…orically, histologically, clinically and molecularly, that the so-called dysplastic nevus is a type of melanocytic nevus and should be managed like other types of melanocytic nevi [1,2]. This reinforces the notion set forth by the late Bernie Ackerma…

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Method for Surgery

…t it is a highly circumscribed one confined to what clinically seem to be benign, mostly exophytic growths such as warts, skin tags, seborrheic keratoses, and the melanocytic nevi of Unna and Miescher types. Those banal lesions may be removed in cosm…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

st is the recognition that cells of a benign neoplasm may have startlingly large and pleomorphic nuclei, e.g., those of some Spitz nevi and of ancient Mieschers nevi, and in reverse, cells of some malignant neoplasms may display remarkably sma…

Dermatology Practical & Conceptual

An atypical pigmented lesion on the nose

…with a paler, raised and scaly central area. [Copyright: ©2014 Savoia et al.] Dermatoscopy with a non-contact polarizing dermatoscope revealed an unspecific pattern, structureless and asymmetric (Figure 2), characterized by blue-gray radial lines, di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…8221; Hutchinson J. Lentigo melanosis: a further report. Arch Surg (Lond) 1894;5:253-256. “It is controversial whether lentigo maligna should be regarded as a form of in situ radial growth phase melanoma or as an atypical potentially premalig…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wide and Deep Excision for Melanoma?

…James WD, Berger TG, Elston DM. Andrews’ Diseases of the Skin. 10th ed. Philadelphia. Elsevier Inc. 2006:699. “wide local excision radial margin was 1.4 cm (median, 1.0 cm)… lymphatic mapping and sentinel lymph node biopsies was su…