Differential Diagnosis in Dermatopathology

Lymphomatoid papulosis vs. Mycosis fungoides, plaque

…melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nod…

Differential Diagnosis in Dermatopathology

Verrucous seborrheic keratosis vs. Verrucous epidermal nevus

…melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly shades of brown. A patch may become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nod…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen striatus

…-12. Patrizi A, Neri I, Fiorentini C, Bonci A, Ricci G. Lichen striatus: clinical and laboratory features of 115 children. Pediatr Dermatol 2004;21(3):197-204. Pinkus F. Ueber eine besondere Form strichförmiger Hautausschläge. Dermatol Z 1904;11:19….

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…in the epidermis at times 4. Individually necrotic keratocytes sometimes; no confluent necrosis 5. Intra-epidermal vesicles or pustules often 5. No intra-epidermal vesicles or pustules 6. Abnormal lymphocytes scattered as solitary units in the ep…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…can be elicited in pemphigus erythematosus, which is a variant subclinical of pemphigus foliaceus. Lupus profundus: Subcutaneous sarcoidosis is less firm, usually is associated with papules, as well as with subcutaneous nodules and tumors, and never…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema figuratum

…t chronique) et de quelques eruptiones analogues. Ann Dermatol Syph 1916;6:57–76. Clark WH, Mihm MC, Reed RJ, Ainsworth AM. The lymphocytic infiltrates of the skin. The lymphocytic infiltrates of the skin. Hum Pathol 1974;5:25. Harrison PV. The annul…

Differential Diagnosis in Dermatopathology

Discussions

…ents with lymphomatoid papulosis, perhaps 10% of them, develop signs of systemic lymphoma. Instead of papules that wax and wane for months or years, as is the usual course of lymphomatoid papulosis, nodules and tumors develop in the skin of patients

Histologic Diagnosis of Inflammatory Skin Diseases

Borreliosis (erythema migrans)

…Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol 2002;40:1249-53. Melski JW, Reed KD, Mitchell PD, Barth GD. Primar…