Differential Diagnosis in Dermatopathology

Differential Diagnosis

…in the epidermis at times 4. Individually necrotic keratocytes sometimes; no confluent necrosis 5. Intra-epidermal vesicles or pustules often 5. No intra-epidermal vesicles or pustules 6. Abnormal lymphocytes scattered as solitary units in the ep…

Differential Diagnosis in Dermatopathology

Discussions

…ents with lymphomatoid papulosis, perhaps 10% of them, develop signs of systemic lymphoma. Instead of papules that wax and wane for months or years, as is the usual course of lymphomatoid papulosis, nodules and tumors develop in the skin of patients

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…can be elicited in pemphigus erythematosus, which is a variant subclinical of pemphigus foliaceus. Lupus profundus: Subcutaneous sarcoidosis is less firm, usually is associated with papules, as well as with subcutaneous nodules and tumors, and never…

Histologic Diagnosis of Inflammatory Skin Diseases

Borreliosis (erythema migrans)

…Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol 2002;40:1249-53. Melski JW, Reed KD, Mitchell PD, Barth GD. Primar…

Differential Diagnosis in Dermatopathology

Discussions

…20;melanocytic nevus.” Melanocytic nevi may be acquired, such as those of Clark, Spitz, and Reed, or be congenital, such as those of Miescher and Unna, and a host of others named by ussuperficial,” “superficial and ‘de…

Differential Diagnosis in Dermatopathology

Lymphomatoid papulosis vs. Mycosis fungoides, plaque

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Differential Diagnosis in Dermatopathology

Verrucous seborrheic keratosis vs. Verrucous epidermal nevus

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

Destombes-Rosai-Dorfman disease Synonyms Rosai-Dorfman disease Rosai-Dorfman histiocytosis Sinus histiocytosis with massive lymphadenopathy Presentation stereotypical Age and sex Usually in males under 25 years of age Distribution of lesions Localiz…