Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

…on the frequent disordered arrangement of the malpighian cells, the nuclear variability and the occasional finding of dyskeratoses and suprabasal mitoses, and concluded that LCA is probably a cytologic variant of Bowens disease [3]. In 1992,…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…igures range from few to many 12. No abnormal mitotic figures 12. Mitotic figures may be abnormal 13. No contiguous superficial squamous-cell carcinoma in the form of solar keratosis or Bowens disease 13. Contiguous solar keratosis or Bowe…

Differential Diagnosis in Dermatopathology

Discussions

…cinoma. In brief, solar keratoses are very superficial squamous-cell carcinomas that may remain superficial for the lifetime of a patient or may grow to become metastasizing squamous-cell carcinoma. The same principle applies to Bowens disease

Differential Diagnosis in Dermatopathology

Verruca vulgaris vs. Verrucous solar keratosis

A malignant neoplasm of keratinocytes that when present as a keratotic macule or papule on skin damaged badly by sunlight is referred to as solar keratosis. When present as a plaque it is termed Bowens disease, and when present as many papule…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…esence of parakeratosis. 11.11.17A: Perivascular dermatosis, psoriasiform lichenoid + 11.11.17B: Keratocytes with large pleomorphic nuclei and evidences of abnormal cornification throughout a thickened epidermis = Bowens disease  At…

Differential Diagnosis in Dermatopathology

Images

Pagetoid Bowens disease Extramammary Paget’s disease

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Pagetoid Bowens disease Extramammary Paget’s disease 1. Parakeratosis usual 1. Orthokeratosis usual 2. No abnormal pale cells in the stratum corneum 2. Abnormal pale cells in the stratum corneum often 3. Epithelial cells with ab…

Dermatology Practical & Conceptual

Introduction to the method

…r of the lesion and converging to a central dot or clod White structureless zone Vessels branched Orange structureless zone or orange clods No lines reticular Squamous-cell carcinoma, superficial (Bowens disease) Clues Multiple vessels as cir…