Differential Diagnosis in Dermatopathology

Verruca vulgaris vs. Verrucous solar keratosis

…tinocytes that when present as a keratotic macule or papule on skin damaged badly by sunlight is referred to as solar keratosis. When present as a plaque it is termed Bowens disease, and when present as many papules in the anogenital region it…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

s of abnormal cornification throughout a thickened epidermis = Bowens disease  At scanning magnification, this superficial expression of squamous-cell carcinoma of one type could be misconstrued as an inflammatory process. By paying heed to at…

Differential Diagnosis in Dermatopathology

Discussions

…are very superficial squamous-cell carcinomas that may remain superficial for the lifetime of a patient or may grow to become metastasizing squamous-cell carcinoma. The same principle applies to Bowens disease. It also is a superficial squamo…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Pagetoid Bowens disease Extramammary Paget’s disease 1. Parakeratosis usual 1. Orthokeratosis usual 2. No abnormal pale cells in the stratum corneum 2. Abnormal pale cells in the stratum corneum often 3. Epithelial cells with ab…

Differential Diagnosis in Dermatopathology

Images

Pagetoid Bowens disease Extramammary Paget’s disease

Dermatology Practical & Conceptual

An atypical pigmented lesion on the nose—Answer

…and conjunctiva [3]. Pigmentation is probably due to cytokines secreted by tumoral cells that stimulate melanocytes to produce melanin [4]. In some cases, PCSCC may be the malignant progression of a pigmented actinic keratosis or a pigmented Bowens

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Solar keratosis Bowens disease 1. Arranged usually in buds or nubbins of epidermis 1. Arranged usually in broadened rete ridges 2. Alternation of ortho- and parakeratosis in fashion repeatable 2. No alternation of ortho- and parakerato…

Differential Diagnosis in Dermatopathology

Images

Solar keratosis Bowens disease