Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…. Lupus panniculitis (LE profundus) 1. With discoid LE 2. With systemic LE II. Subacute cutaneous LE A. Papulosquamous B. Annular C. Syndromes commonly exhibiting similar morphology 1. Neonatal LE 2. Complement deficiency syndrome III. Acute cutaneou…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

…(e.g., the “hot comb”) and onset, progression, or severity of disease. The histologic features of FDS in men are identical to those in women.” Sperling LC, Skelton HG III, Smith KJ, Sau P, Friedman K. Follicular degeneration syndr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidemic of Melanoma?

…ere flat. Illustrative of this deficiency are photomicrographs shown by Allen in the 1950s in his textbook and in articles in Cancer, captioned “Active junctional nevus;” every one of those is melanoma in situ indubitable. In short, flat…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…or cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO: CV Mosby Co….

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…absence of trauma. Desmoplastic melanoma is more asymmetrical, subtly variegate in color, and unaffiliated with a “dimple sign.” Spitz’s nevus may be red, orange, or pink, as well as brown or black, but it is not firm unless it is w…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphadenosis benigna cutis

…cal Lymphoma may be indistinguishable. When the breast is the site affected, primary carcinoma must be considered. Tick “bite” and assaults by other arthropods may be identical. Spitz’s nevus often presents itself as a pink, red, o…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Spitz’s Nevus, Compound Type Melanoma 1. Symmetric 1. Asymmetric 2. Sharp circumscription 2. Poor circumscription 3. Maturation of melanocytes (decrease in size of aggregations and of nuclei) with descent progressive 3. No maturation w…