Histologic Diagnosis of Inflammatory Skin Diseases

Scar

Scar Synonyms Cicatrix Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Usually localized, but sometimes widespread Configuration of lesions Linear, as in a surgical wound Round, as a consequence of an ulcer ind…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…or cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO: CV Mosby Co….

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…absence of trauma. Desmoplastic melanoma is more asymmetrical, subtly variegate in color, and unaffiliated with a “dimple sign.” Spitz’s nevus may be red, orange, or pink, as well as brown or black, but it is not firm unless it is w…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphadenosis benigna cutis

…cal Lymphoma may be indistinguishable. When the breast is the site affected, primary carcinoma must be considered. Tick “bite” and assaults by other arthropods may be identical. Spitz’s nevus often presents itself as a pink, red, o…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Spitz’s Nevus, Compound Type Melanoma 1. Symmetric 1. Asymmetric 2. Sharp circumscription 2. Poor circumscription 3. Maturation of melanocytes (decrease in size of aggregations and of nuclei) with descent progressive 3. No maturation w…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Dermatofibroma Desmoplastic Spitz’s nevus 1. Acanthotic epidermis often associated with induction of folliculo-sebaceous units 1. Little or no acanthosis; no induction of folliculo-sebaceous units 2. Epidermis often thinned above the cen…

Differential Diagnosis in Dermatopathology

Images

Dermatofibroma Desmoplastic Spitz’s nevus

Differential Diagnosis in Dermatopathology

Images

Spitz’s Nevus, Compound Type Melanoma…

Differential Diagnosis in Dermatopathology

Discussions

…histiocytes positioned mostly in the upper part of the dermis, sometimes in palisaded array and sometimes as solitary units splayed between bundles of collagen. Moreover, both conditions exhibit lymphocytes around venules and extracellular deposits o…

Histologic Diagnosis of Inflammatory Skin Diseases

Polyarteritis nodosa

Polyarteritis nodosa Synonyms Periarteritis nodosa Panarteritis nodosa Kussmaul-Maier disease Kussmaul-Maier syndrome Polyarteritis acuta nodosa Presentation stereotypical Age and sex Men mostly Distribution of lesions Bilateral, particularly on the…