Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

…actors for metastasis may include relatively large size, high cellularity, and local recurrence. It would appear that metastasizing dermatofibromas behave in an indolent manner, judging from the two cases presented here. Dermatofibroma thus joins the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Colors Stereotypical for Diseases Specific?

…rance of lymphangiomas and for the cherry red in that type of hemangioma known inaccurately as “senile.” It is important that dermatologists be alert to the effect of color of normal skin on the color of lesions cutaneous. For example, le…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Fibromatoses?

…nge from those composed largely of dense collagen with sparse spindle cells to densely cellular tumor-appearing masses. Classification: Palmar, plantar and penile fibromatosis Desmoid (Aggressive fibromatosis)” Cotran RS, Kumar V, Robbins SL. T…

Differential Diagnosis in Dermatopathology

Morphea, late stage vs. Collagenous nevus

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…obular + 10.70.2B: Interwoven fascicles of plump oval and spindle-shaped fibrocytes in conjunction with fibrillary bundles of collagen, abundant mucin, scattered lymphocytes, and extravasated erythrocytes = Nodular fasciitis  This condition funda…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ion of collagen bundles by acid mucopolysaccharides 5. Mast cells increased markedly in regions mucinous 5. Mast cells increased slightly in loci mucinous 6. Fibrocytes increased slightly and scattered as solitary units in stroma, mucin-rich, mos…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Histologic Diagnosis of Inflammatory Skin Diseases

Nodular fasciitis

…al diagnosis histopathologic Fibrosarcoma exhibits abnormal spindle cells arranged in fascicles that tend to assume a herringbone pattern and does not display either abundant mucin or, as a finding consistent, an infiltrate of inflammatory cells….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…throughout the dermis and an increased number of stellate and spindle-shaped fibrocytes in the upper part of it = Radiation dermatitis, chronic  The findings in longstanding lesions of radiation dermatitis differ from those of morphea by sclerosis be…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…ump fibrocytes that act in a manner comparable to mesenchymal cells of a follicular papilla in an embryo, those cells bring forth the entire infundibulo-apocrine-sebaceous-follicular unit. Low-grade fibrosarcoma consists of abnormal spindle cells arr…